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Poster Abstract Presentations

Abstract 291: In Situ Re-endothelialization via Multifunctional Nanoscaffolds

Lee-Chun Su, Hao Xu, Richard T Tran, Yi-Ting Tsai, Liping Tang, JIan Yang, Kytai T Nguyen
Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A291
Lee-Chun Su
Bioengineering, The Univ of Texas at Arlington, Arlington, TX
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Hao Xu
Cardiology, The Univ of Texas Southwestern Med Cntr at Dallas, Dallas, TX
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Richard T Tran
Bioengineering, The Pennsylvania State Univesity, Univ Park, PA
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Yi-Ting Tsai
Bioengineering, The Univ of Texas at Arlington, Arlington, TX
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Liping Tang
Bioengineering, The Univ of Texas at Arlington, Arlington, TX
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JIan Yang
Bioengineering, The Pennsylvania State Univ, Univ Park, PA
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Kytai T Nguyen
Bioengineering, The Univ of Texas at Arlington, Arlington, TX
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Abstract

The endothelium monolayer lining in the luminal side of blood vessels provides critical anti-thrombotic activities. Damage to these cells will expose a highly thrombogenic subendothelium that stimulates thrombosis. Standing on the concept of tissue engineering and ligand-receptor targeting strategy, we developed a novel biodegradable urethane-doped polyester (UPE) multifunctional targeting nanoparticle (MTN) scaffold system with dual ligands: 1) GP1b-α to target the injured arterial endothelium and subendothelium and 2) anti-CD34 antibodies to capture endothelial progenitor cells (EPCs) for endothelium regeneration. The fabricated spherical MTNs of 400 nm were shown to be biocompatible and hemocompatible. Both the in vitro and ex vivo targeting of these nanoscaffolds not only showed improved binding efficiency of MTNs onto the von Willebrand Factor (vWF) coated surfaces presented as the injured arterial walls, but also outperformed platelets for binding onto these injured sites. Our in vivo study further showed 57% neointimal hyperplasia suppression and a 70% increase in endothelium regeneration within 21 days after delivering of MTNs upon vascular injury. These results indicate that our injectable MTN nanoscaffolds show a potential non-invasive way for endothelium regeneration in situ.

  • endothelial progenitor cells
  • nanoscaffolds
  • endothelialization in situ
  • © 2013 by American Heart Association, Inc.
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Arteriosclerosis, Thrombosis, and Vascular Biology
April 2018, Volume 38, Issue 4
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    Abstract 291: In Situ Re-endothelialization via Multifunctional Nanoscaffolds
    Lee-Chun Su, Hao Xu, Richard T Tran, Yi-Ting Tsai, Liping Tang, JIan Yang and Kytai T Nguyen
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A291, originally published October 20, 2015

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    Abstract 291: In Situ Re-endothelialization via Multifunctional Nanoscaffolds
    Lee-Chun Su, Hao Xu, Richard T Tran, Yi-Ting Tsai, Liping Tang, JIan Yang and Kytai T Nguyen
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A291, originally published October 20, 2015
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