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Poster Abstract Presentations

Abstract 235: Macrophage Depletion Reduces Angiotensin Ii-induced Aortic Inflammation but Not Experimental Aneurysm Formation

Keith J Glover, Baohui Xu, Haojun Xuan, Hiroki Tanaka, Taku Nagai, Naoki Fujimura, Yasunori Iida, Wei Wang, Yuko Furusho, Masaaki Miyata, Sara A Michie, Takami Matsuyama, Ronald L Dalman
Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A235
Keith J Glover
Vascular Surgery, Stanford Univ Sch of Medicine, Stanford, CA
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Baohui Xu
Vascular Surgery, Stanford Univ Sch of Medicine, Stanford, CA
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Haojun Xuan
Vascular Surgery, Stanford Univ Sch of Medicine, Stanford, CA
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Hiroki Tanaka
Vascular Surgery, Stanford Univ Sch of Medicine, Stanford, CA
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Taku Nagai
Immunology, Kagoshima Univ Sch of Medicine, Kagoshima, Japan
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Naoki Fujimura
Vascular Surgery, Stanford Univ Sch of Medicine, Stanford, CA
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Yasunori Iida
Vascular Surgery, Stanford Univ Sch of Medicine, Stanford, CA
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Wei Wang
Vascular Surgery, Stanford Univ Sch of Medicine, Stanford, CA
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Yuko Furusho
Immunology, Kagoshima Univ Sch of Medicine, kagoshima, Japan
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Masaaki Miyata
Medicine, Kagoshima Univ Sch of Medicine, kagoshima, Japan
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Sara A Michie
Pathology, Stanford Univ Sch of Medicine, Stanford, CA
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Takami Matsuyama
Immunology, Kagoshima Univ Sch of Medicine, kagoshima, Japan
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Ronald L Dalman
Vascular Surgery, Stanford Univ Sch of Medicine, Stanford, CA
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Abstract

Massive mural macrophage infiltration is observed in experimental and clinical abdominal aortic aneurysm (AAA) disease. However, causational relationships, if any, between macrophage infiltration and aneurysm pathogenesis remain uncertain. This study examined the consequences of total and activated macrophage depletion on aneurysm formation and progression in the angiotensin II infusion, apolipoprotein E-deficient (Ang II/Apo E-/-) AAA model. Mice were evaluated via serial in vivo aortic ultrasonography for 28 days during the Ang II infusion, and histology at sacrifice. In CD11b-diphtheria toxin (DT) receptor transgenic (DT+) Ang II/ApoE-/- mice, DT injection failed to prevent aneurysm formation despite successful macrophage depletion. AAAs developed in 40% of DT+ Ang II/ApoE-/- mice, a rate similar to littermate control, DT- Ang II/ApoE-/- receiving Ang II and DT. Similar results were observed when Ang II/Apo E-/- mice were treated with folate receptor (FR) β immunotoxin (to deplete activated macrophages characterized by FRβ expression) compared with control toxin. Histologically, DT treatment in DT+ Ang II/ApoE-/- mice reduced aortic CD68+ mural macrophages by 77% and 60% in mice with or without aneurysms, respectively. Similarly, activated macrophage depletion via FRβ immunotoxin resulted in a 33% and 50% reduction in mural CD68+ macrophages in mice with and without aneurysms, respectively. In conclusion, neither the total or activated mural macrophages appear to mediate aneurysmal aortic enlargement in the Ang II/ApoE-/- AAA model.

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April 2018, Volume 38, Issue 4
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    Abstract 235: Macrophage Depletion Reduces Angiotensin Ii-induced Aortic Inflammation but Not Experimental Aneurysm Formation
    Keith J Glover, Baohui Xu, Haojun Xuan, Hiroki Tanaka, Taku Nagai, Naoki Fujimura, Yasunori Iida, Wei Wang, Yuko Furusho, Masaaki Miyata, Sara A Michie, Takami Matsuyama and Ronald L Dalman
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A235, originally published October 20, 2015

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    Abstract 235: Macrophage Depletion Reduces Angiotensin Ii-induced Aortic Inflammation but Not Experimental Aneurysm Formation
    Keith J Glover, Baohui Xu, Haojun Xuan, Hiroki Tanaka, Taku Nagai, Naoki Fujimura, Yasunori Iida, Wei Wang, Yuko Furusho, Masaaki Miyata, Sara A Michie, Takami Matsuyama and Ronald L Dalman
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A235, originally published October 20, 2015
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