Abstract 200: Geographical Location and Gender are Predictors of Elevated High Sensitive C-Reactive Protein (hsCRP) Levels and the Levels Strongly Correlate with Metabolic Syndrome (MetS) in a South Asian Population
Background hsCRP is a risk factor for MetS. However, the distribution of hsCRP levels and its association with MetS in South Asians is unclear.
Methods We conducted a population-based cross-sectional survey in 8,042 Indians (44% males, 56% females), age ≥20 yrs in urban (n=5, 017) and rural (n=3,025) communities. The study included anthropometric measurements, and fasting blood for plasma glucose, hsCRP and lipids. MetS was defined using NCEP (ATP III) criteria for Asians.
Results The median hsCRP level was 2.30 mg/l [95% confidence interval (CI) 2.24, 2.39]. Adjusting for age and BMI, the hsCRP level was significantly higher in women, median 2.86 [CI 2.73, 2.97] when compared to men, median 1.80 [CI 1.71, 1.88] (p-value < 10-9). Adjusting for gender, age & BMI the urban communities had significantly higher hsCRP levels versus rural (p-value = 0.03). The fig. shows the distribution of hsCRP according to the number of components of MetS. The median hsCRP for those with 0, 1, 2, 3, 4, and 5 features of MetS are 1.01, 1.47, 2.3, 3.19, 3.70 and 3.94, respectively. Based on Kruskal-Wallis H test, after adjusting the hsCRP for gender, age and community, hsCRP levels were significantly higher in individuals with more components of MetS (p-value < 10-9 for trend). hsCRP and BMI were relatively independent predictors of MetS. Prevalence of MetS was higher in women (prevalence ratio [PR] = 1.15; CI 1.09, 1.21) and in urban communities (PR = 1.47; CI 1.35, 1.66).
Conclusions hsCRP is highly associated with the MetS and the number of positive MetS components. Geographical location and gender are predictors of hsCRP levels, which is associated with a higher incidence of MetS in urban communities and women.
- © 2013 by American Heart Association, Inc.