Abstract 157: Association of Cholesterol Profile to the Number of Vessels Involved with Coronary Artery Disease
Introduction The cholesterol profile is an important modifiable risk factor for CAD and our understanding of atherosclerosis has helped develop drugs that have significantly impacted treatment outcomes of CAD by lowering cholesterol levels. A study to find a correlation between the cholesterol profile and the number of vessels involved with CAD was our objective.
Hypothesis Patients with significant CAD (defined as >50% stenosis on coronary angiography) in 2 or more vessels had worse cholesterol profiles compared to single vessel. A subset of the study looked to see if the use of statins affected the severity of CAD.
Methods A retrospective review of 498 patients from our hospitals cardiac registry was done. The cholesterol profile of these patients done either during the admission for cardiac catherization or the most recent one was used to correlate. The catheterization reports were reviewed to find the number of vessels involved with >50% stenosis and a CAD severity score was calculated using the gensini scoring system. We also reviewed the patients medication reconciliation forms to see if they had been on statins.
Results We could not correlate between the number of vessels affected with significant CAD and the cholesterol profile. Using One way ANOVA analysis neither the Tc/HDL ratio ( p value 0.692) or LDL (p value=0.458) or the HDL levels( p value=0.588) had any association to the number of coronary vessels affected with CAD. In our study subset, the use of statins did not lower the gensini scores significantly as compared to patients who were not on statins (p value 0.95).
Conclusions The cholesterol profile bears no correlation with the number of vessels affected by CAD. Based on our findings, taking statins did not significantly influence the severity of CAD.
- © 2013 by American Heart Association, Inc.