Abstract 473: Relationship of White Blood Cell Count with Coronary Atherosclerosis by Calcium Scores and Epicardial Fat Burden in Patients with Acute Chest Pain
Background: Elevated white count ( WBC) as inflammatory marker has been associated with more severe CAD and worse outcome in patients with acute myocardial infarction (MI). However, the relationship between total white count and calcium score (CACS) and epicardial fat (EAT) in patients with acute chest pain but no MI is not known.
Methods: : CACS was evaluated by non contrast cardiac computed tomography in 974 consecutive patients with no history of CAD but admitted with acute chest pain and no MI by ECG and enzymes. Epicardial fat volume was measured in 713 pts . We divided the WBC count by the median and then at 10 K ( close to top quartile) . Pearson’s correlation was used to test association between log (CAC +1) and epicardial fat volume .
Results: The mean age for this population was 57.4 with 60 % female. The predominant race was Caucasians (60%). The mean Framingham score was 8.16 ± 8.15. The mean WBC was 7.8± 4.38 ( x 10 K) . The median WBC was 7.3 x 10k. The mean CACS and EAT volume did not differ between the groups when different cut off of WBC was used ( see table)
There is no difference in the prevalence of CACS >0 or moderate CACS ( > 100) in different WBC group ( for WBC > 10 K 17 % has CACS > 100 vs 18 % in WBC <=10K p = NS) ) Similar result was found on the EAT volume analysis. The only predictor of CACS was age, FRS and EAT volume (log (CAC +1) vs epicardial volume: correlation coefficient 0.266 p <0.001).
Conclusion: WBC does not predict calcium scores or epicaridal fat volume in patients with acute chest pain .
- © 2012 by American Heart Association, Inc.