Abstract 435: Increased Serum Level of Cholesterol Decreases 3-Month Mortality After Acute Ischemic Stroke
Introduction: Recently, it was reported that obesity, one of the risk factor for cardiovascular diseases, paradoxically decreased mortality in patients with coronary heart disease. Nutritional status associated with obesity may play a role on this paradoxical effect, and cholesterol is also an indicator of nutritional status. Although cholesterol is a well-known risk factor for ischemic stroke, according to prognostic effect of cholesterol on ischemic stroke few studies have been done. We investigated whether cholesterol levels after acute ischemic stroke are associated with early-mortality.
Methods: We prospectively included patients with acute ischemic stroke admitted consecutively to our hospital, from October 2002 to October 2008. A total of 2,313 patients were analyzed for this study. Cholesterol levels were measured from fasting blood samples which were drawn within 24 hours of admission. For the analyses of mortality, the patients were divided by baseline measurements into quartiles of cholesterol levels (5.23 mmol/L). Patients were followed for 3-months from enrollment into the study, and mortality data were collected.
Results: The three-month mortality rate in the highest quartile of cholesterol was significantly lower than in the lowest quartile (2.1% versus 6.4%, p<0.05). After adjusting possible confounders including age, gender, hypertension, diabetes, smoking, stroke severity and subtypes, and statin use with the Cox proportional hazard models, adjusted hazard ratio of the highest quartile for all-cause death was 0.49 (95% confidence interval 0.25-0.95).
Conclusion: Our study demonstrated that increased serum level of cholesterol paradoxically decreases three-month mortality after acute ischemic stroke.
- © 2012 by American Heart Association, Inc.