Abstract 423: High-Risk Plaque in the Carotid and Femoral Arteries of Men and Women with Peripheral Arterial Disease: Prevalence and Clinical Correlations
OBJECTIVES. It is currently unknown whether high-risk atherosclerotic plaque develops simultaneously in multiple arterial beds or whether it is an isolated phenomenon. We used direct plaque imaging with magnetic resonance imaging (MRI) in participants with lower extremity peripheral arterial disease (PAD) to determine whether individuals with lipid rich necrotic core (LRNC) in the femoral arteries have a higher prevalence of LRNC in the carotid arteries than individuals without LRNC in the femoral arteries.
METHODS AND RESULTS. Twenty-four participants with PAD underwent direct plaque imaging of both their carotid and superficial femoral arteries. Four participants (16.7%) had LRNC in the femoral artery and 18 (75%) had LRNC in the carotid artery (P<0.001). The prevalence of LRNC in the carotid arteries was 75% among participants with LRNC in the femoral arteries vs. 75% among participants without LRNC in the femoral arteries (P=1.00). Mean ages were 69.0+8.7, 61.9+9.6, and 63.7 +3.8 among participants with LRNC in neither the carotid or femoral arterial beds, in only one of the arterial beds, and in both the arterial beds, respectively, (P=0.27). Among participants with LRNC in neither arterial bed, only one arterial bed, and both arterial beds, mean ABI values were 0.62+0.08, 0.76+ 0.12, and 0.57 + 0.14 (P=0.02), prevalences of cigarette smoking were 20.00%, 56.25%, and 66.67% (P=0.30), and prevalences of males were 80.0%, 93.75%, and 100%, respectively.
CONCLUSION. Among people with PAD, the prevalence of plaque containing LRNC is higher in the carotid than in the femoral arteries. The prevalence of femoral artery LRNC is similar between participants with vs. without carotid artery LRNC.
- © 2012 by American Heart Association, Inc.