Abstract 393: Osteoporosis Equals Atherosclerosis
Atherosclerosis and osteoporosis are the leading causes of mortality and morbidity in the World. Recent epidemiologic studies have demonstrated that these disease processes develop in parallel. Evidence indicates that hyperlipidemia plays a paradoxical role in both disease processes. However, the mechanism is not understood. We hypothesize lipids activate atherosclerosis within the bone and the heart to initiate the development of diseases in both of these tissues. To test this hypothesis in an experimental hypercholesterolemia model and to determine if statins play a protective role in this process. LDLR-/- mice (n=60). Group I (n=20) normal diet, Group II (n=20) 0.25% chol diet (w/w), and Group III (n=20) 0.25% (w/w) chol diet+atorv for the development of calcification. The aortic valves(AVA) and femurs were examined for atherosclerosis and calcification markers. Bone formation was assessed by micro Computed Tomography (microCT). The cholesterol diet induced complex bone formations in the calcified AVA and increase in macrophage cell infiltration. The hyperlipidemic bones expressed an increase in osteoclast Goldner Stained cells and a decrease in bone formation by MicroCT. Atorvastatin reduced atherosclerosis and bone mineralization in the AVA and increased mineralization within the femur bones(p<0.05). Atherosclerosis is present in hyperlipidemic bones and valves as characterized by the hallmarks of atherosclerosis, macrophage and osteoclast infiltration, and which is attenuated by atorvastatin. This model may have future implications in the treatment of cardiovascular calcification and osteoporosis with statin therapy.
- © 2012 by American Heart Association, Inc.