Abstract 381: Favorable Effects of Habitual Physical Activity on Vascular Function: Ikaria Study
Background: Physical activity (PA) has substantial vascular and cardiac health benefits and can ameliorate cardiac risk. Measurement of endothelial function is well validated in large population studies as strong predictor of adverse cardiovascular outcomes. In the present study we evaluated the effect of habitual physical activity on vascular function in residents of Ikaria Island. The inhabitants of this island show increased longevity and high prevalence of healthy aging.
Methods: The study was conducted on a subgroup population of IKARIA study consisted of 327 subjects (155 men) aged 40-91 years, permanent inhabitants of Ikaria Island. Endothelial function was evaluated by ultrasound measurement of flow-mediated-dilatation (FMD). We evaluated PA using the shortened version of the self-reported International Physical Activity Questionnaire (IPAQ). Overall the study sample was divided in three groups according to the categorical score achieved in IPAQ questionnaire: low PA (n=75), moderate PA (n=200) and vigorous PA (n=48). Subjects in the low PA group were recorded as physical inactive and the rest as physical active.
Results: Mean FMD (5.79±3.19%) was inversely associated with age (r=-0.242, p<0.001). Inactive subjects had significantly lower FMD compared to active subjects (4.95±3.02% vs. 6.06±3.23%, p=0.008). Multiple linear regression analysis after adjustment for several known confounders (age, diabetes mellitus, hypertension, smoking, hypercholesterolemia, cardiovascular disease, body mass index) revealed significant differences in FMD values between moderate vs. low PA group [b=1.24, 95%CI: (0.28, 2.20), p=0.011] whereas a trend was evident between vigorous and low PA group [b=1.11, 95%CI: (-0.16, 2.38), p=0.089]. Moreover subjects walking for more than 10 minutes less than two times weakly had significantly lower FMD compared with subjects walking three to five days weakly or almost every day (5.13±2.82% vs. 6.95±3.84% vs. 6.00±3.23%, p=0.005).
Conclusions: The present study revealed another cardioprotective mechanism of habitual PA through beneficial modification of endothelium function.
- © 2012 by American Heart Association, Inc.