Abstract 346: Change in Alcohol Consumption Status Associated with Changes in Fibrinogen Levels over 13 Years of Follow-up: The Coronary Artery Risk Development in Young Adults Study
Introduction: Moderate alcohol consumption is inversely related to coronary/cardiovascular disease (CVD) risk and mortality. Conversely, fibrinogen has been positively associated with atherosclerosis and thrombosis. No studies to date have examined longitudinal associations between alcohol consumption and blood fibrinogen levels.
Methods: We included 2548 CARDIA participants (55% women, 43% black) with fibrinogen and alcohol use data at year 7 (1992-93; ages 25-37) and year 20 examinations (2005-06). Fibrinogen was measured using automated nephelometry. Alcohol use was self-reported and categorized as current, former or never drinkers at each exam. ANCOVA models were used to relate changes in alcohol use to changes in mean fibrinogen levels stratified by sex and race, after controlling for year 7 fibrinogen. Subsequent models also adjusted for conventional cardiovascular risk factors (Figure).
Results: Over 13 years, mean fibrinogen increased by 71mg/dL vs. 70mg/dL (p-difference=NS) in black men (BM) vs. white men (WM), and 78mg/dL vs. 68mg/dL (p-difference<0.05) in black women (BW) vs. white women (WW), respectively. The Pearson’s correlation coefficients between years 7 and 20 fibrinogen were 0.60 (BM), 0.47 (WM), 0.54 (BW) and 0.53 (WW) (each p<0.001). Compared with never-drinkers, becoming or staying a drinker was associated with a smaller longitudinal increase in fibrinogen for BM, BW and WW after multivariable adjustment (Figure). Conversely, WM who stayed drinkers had a larger increase in fibrinogen (p<0.01). Relative to never-drinkers, fibrinogen increased more among BM (p<0.05), WM (p<0.001) and WW (p=NS) who were no longer alcohol users by year 20.
Conclusions: In this young cohort, we observed an inverse longitudinal relationship between alcohol consumption and fibrinogen in BM, BW and WW. These results provide a novel insight into the mechanism for established protective effect of moderate alcohol intake on CVD outcomes.
- © 2012 by American Heart Association, Inc.