Abstract 326: MicroRNA-30c Reduces Hyperlipidemia and Atherosclerosis by Decreasing Lipid Synthesis and Lipoprotein Secretion
Hyperlipidemia is a risk factor for various cardiovascular and metabolic disorders. Overproduction of lipoproteins, a process critically dependent on microsomal triglyceride transfer protein (MTP), can contribute to hyperlipidemia. We show that microRNA-30c (miR-30c) interacts with the 3’-untranslated region of the MTP mRNA and induces degradation leading to reductions in apolipoprotein B secretion in cells. Further, miR-30c reduces hyperlipidemia and atherosclerosis in Western diet fed mice by decreasing lipid biosynthesis as well as assembly and secretion of triglyceride-rich apoB-containing lipoproteins without increasing either hepatic lipids or plasma transaminases. Therefore, miR-30c coordinately reduces lipid biosynthesis and lipoprotein secretion to control cellular and plasma lipid levels and might be useful in treating hyperlipidemia and associated disorders.
- © 2012 by American Heart Association, Inc.