Abstract 174: Carboxylesterase 1 in Lipid Metabolism and Obesity
Over-expression of human carboxylesterase 1 (CES1) in macrophages has been shown to increase hydrolysis of cholesterol esters and protect against atherosclerosis. However, the role of CES1 in other tissues and the physiological functions of CES1 are largely unknown. In this report, we investigated the role of CES1 in the liver. Over-expression of hepatic CES1 decreased hepatic triglyceride and plasma cholesterol levels. In contrast, knock down of hepatic CES1 by shRNA led to increased hepatic triglyceride levels and plasma LDL-C levels. To understand the physiological functions of CES1, we generated Ces1-/- mice. Ces1-/- mice are resistant to diet-induced obesity and showed changes in hepatic and plasma lipid levels. We also investigated the mechanisms underlying these changes. Our data indicate that CES1 plays a critical role in regulating lipid and energy homeostasis.
- © 2012 by American Heart Association, Inc.