Introduction for National Cholesterol Month
In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, there is a special collection of articles in recognition of National Cholesterol Month. As Brown and Goldstein noted in 1985 in their Nobel Prize lecture, “Cholesterol is the most highly decorated small molecule in biology. Thirteen Nobel Prizes have been awarded to scientists who devoted major parts of their careers to cholesterol. Ever since it was first isolated from gallstones in 1784, almost exactly 200 years ago, cholesterol has exerted a hypnotic fascination for scientists from the most diverse domains of science and medicine.”1
The authors and readers of Arteriosclerosis, Thrombosis, and Vascular Biology remain fascinated by cholesterol, and the range of “domains” remains diverse. The articles in this issue span a wide range of topics, including the effects of oxidized low-density lipoprotein on signal transduction in endothelial cells, a number of contributors to macrophage foam cell formation, and cholesterol crystallization and plaque rupture.
The long tradition of research on cholesterol has led to fundamental discoveries about a two-faced molecule: not only is it essential to life, but its excess in the vasculature underlies the major cause of death in the developed world. Progress in understanding both faces will come from continued research efforts, such as those represented in this issue, and we hope that this “small molecule” will be decorated many times over in the years to come, reflecting further major advances in our understanding of its role in macrovascular disease.
Articles in this series
Fisher EA. Introduction for National Cholesterol Month. Arterioscler Thromb Vasc Biol. 2011;31:1939–1940.
Nakajima K, Yamashita T, Kita T, Takeda M, Sasaki N, Kasahara K, Shinohara M, Rikitake Y, Ishida T, Yokoyama M, Hirata K-i. Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2011;31:1963–1972.
Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H. Macrophage elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2011;31:1973–1979.
Ogura M, Ayaori M, Terao Y, Hisada T, Iizuka M, Takiguchi S, Uto-Kondo H, Yakushiji E, Nakaya K, Sasaki M, Komatsu T, Ozasa H, Ohsuza F, Ikewaki K. Proteasomal inhibition promotes ATP-binding cassette transporter 1 (ABCA1) and ABCG1 expression and cholesterol efflux from macrophages in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2011;31:1980–1987.
Patel R, Janoudi A, Vedre A, Aziz K, Tamhane U, Rubinstein J, Abela OG, Berger K, Abela GS. Plaque rupture and thrombosis are reduced by lowering cholesterol levels and crystallization with ezetimibe and are correlated with fluorodeoxyglucose positron emission tomography. Arterioscler Thromb Vasc Biol. 2011;31:2007–2014.
Wang M, Li W, Chang G-Q, Ye C-S, Ou J-S, Li X-X, Liu Y, Cheang T-Y, Huang X-L, Wang S-M. MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomysin 1 in arteriosclerosis obliterans of lower extremities. Arterioscler Thromb Vasc Biol. 2011;31:2044–2053.
Quinn KL, Henriques M, Tabuchi A, Han B, Yang H, Cheng W-E, Tole S, Yu H, Luo A, Charbonney E, Tullis E, Lazarus A, Robinson LA, Ni H, Peterson BR, Kuebler WM, Slutsky AS, Zhang H. Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation. Arterioscler Thromb Vasc Biol. 2011;31:2070–2079.
Shi Y, Cosentino F, Camici GG, Akhmedov A, Vanhoutte PM, Tanner FC, Lüscher TF. Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-β, and c-Jun N-terminal kinase kinase in human endothelial cells. Arterioscler Thromb Vasc Biol. 2011;31:2100–2107.
Lewandowski AJ, Lazdam M, Davis E, Kylintireas I, Diesch J, Francis J, Neubauer S, Singhal A, Lucas A, Kelly B, Leeson P. Short-term exposure to exogenous lipids in premature infants and long-term changes in aortic and cardiac function. Arterioscler Thromb Vasc Biol. 2011;31:2125–2135.
Nguyen Ab, Rohatgi A, Garcia CK, Ayers CR, Das SR, Lakoski SG, Berry JD, Khera A, McGuire DK, de Lemos JA. Interactions between smoking, pulmonary surfactant protein B, and atherosclerosis in the general population: the Dallas Heart Study. Arterioscler Thromb Vasc Biol. 2011;31:2136–2143.
- © 2011 American Heart Association, Inc.
- Brown MS,
- Goldstein JL