Series Editor: Ziad Mallat
ATVB In Focus
Monocyte Subsets and Their Relevance to Cardiovascular Diseases
Articles in this series:
•Gautier EL, Jakubzick C, Randolph GJ. Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:1412–1418.
•Mantovani A, Garlanda C, Locati M. Macrophage diversity and polarization in atherosclerosis: a question of balance. Arterioscler Thromb Vasc Biol. 2009;29:1419–1423.
•Swirski FK, Weissleder R, Pittet MJ. Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:1424–1432.
•Shantsila E, Lip GYH. Monocytes in acute coronary syndromes. Arterioscler Thromb Vasc Biol. 2009;29:1433–1438.
Monocytes and macrophages are critically involved in the development, progression and complications of atherosclerosis. In the last ten years, we witnessed incredible progress in our understanding of the biology of these innate immune cells with the identification of a common monocyte progenitor for macrophages and dendritic cells and the description of different monocyte and macrophage subsets endowed with specific biological activities that are dramatically influenced by their microenvironments. The current knowledge suggests that specific subsets of monocytes and monocyte-derived cells are differentially involved in distinct pathophysiological steps during atherogenesis and other types of tissue responses to injury. The current series of reviews summarize the most current knowledge in a rapidly expanding field relevant to not only atherosclerosis, but to many conditions with an inflammatory component.