Dr Jeffrey M. Hoeg died July 21, 1998, following a short, courageous battle with renal cancer. Jeff’s death at the young age of 46 was a terrible loss to his colleagues and to the fields of hyperlipidemia and cardiovascular disease. Jeff was a remarkable physician-scientist with a charismatic personality, an infectious smile, and a wonderful sense of humor. He thoroughly enjoyed life and was a joy to be around. Each of us benefited from Jeff’s warmth, enthusiasm, and positive attitude. Jeff was a superb role model, both as a physician-scientist and mentor, as well as a friend of young investigators. He guided each young scientist with great care and insight as their careers blossomed under his tutelage. In addition to being an outstanding investigator, Jeff was an excellent physician and was loved by his patients. He had a particular interest in children with familial hypercholesterolemia and played a central role in the development of new and innovative treatment programs for these patients with very high cholesterol levels. Jeff was internationally known for the treatment of familial hypercholesterolemia and patients were referred to his care from around the world.
Jeff made several significant contributions to both basic and clinical research in the fields of lipoproteins and cardiovascular disease. Of particular importance was the challenging development of transgenic rabbits as a model system for the study of lipoprotein metabolism and atherosclerosis. The generation of the transgenic rabbit as a useful animal model is Jeff’s legacy to the field of cardiovascular disease.
Jeff was a native of Indiana and received his undergraduate and medical degrees with honors from Indiana University. Jeff completed his internship and residency in internal medicine at Barnes Hospital and was chief resident at the Veterans Administration Hospital in St Louis. He joined the staff of the Molecular Disease Branch in the National Heart, Lung, and Blood Institute, National Institutes of Health, as a research associate in 1980, and was appointed Head, Section of Cell Biology in 1991.
Jeff was a member of several professional organizations, including the American Heart Association’s Council on Arteriosclerosis, Thrombosis, and Vascular Biology, American Association for the Advancement of Science, and the American Federation of Medical Research. In addition, he was on the Board of Governors of the American College of Cardiology and was a fellow of both the American College of Physicians and the American College of Cardiology. He also served on the editorial boards of several journals including the American Journal of Cardiology and the Journal of Biological Chemistry. His keen insight into the role of clinical research in medicine was reflected in his appointment to the Board of Governors for the National Institutes of Health Clinical Center to help guide clinical research into the 21st century.
Jeff is survived by his beloved wife, Nancy Jean Hoeg, 2 daughters, Jessica Jean Hoeg and Laura Nicole Hoeg, his parents, Kenneth and Patricia Hoeg, and 2 sisters.