on April 16, 2009
Published online before print April 16, 2009, doi: 10.1161/ATVBAHA.109.186783
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Submitted on October 1, 2008
Accepted on April 1, 2009
Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons. The Health, Aging, and Body Composition (Health ABC) Study
Javed Butler *;
From Emory University (J.B., A.K., V.G., A.L.S., P.W.F.W.), Atlanta Ga; Epicenter (N.d.R.), Paris, France; the University of Lausanne (N.R.), Switzerland; Massachusetts General Hospital (U.H.), Harvard Medical School, Boston Mass; University of California San Francisco (A.K.); University of Pittsburgh (A.B.N.), Pa; Wake Forest University (S.B.K.), Winston Salem NC; Boston University School of Medicine (R.S.V.), Mass; and the Intramural Research Program (T.B.H.), National Institute of Aging, National Institutes of Health, Bethesda, Md.
* To whom correspondence should be addressed. E-mail: javed.butler{at}emory.edu.
Objective—Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans.
Methods and Results—We studied 2902 older persons without prevalent HF (age, 73.6±2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3±10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho <0.25). During a median follow-up of 9.4 years, 341 participants (11.8%) developed HF. Resistin was strongly associated with risk for incident HF in Cox proportional hazards models controlling for clinical variables, biomarkers, and measures of adiposity (HR, 1.15 per 10.0 ng/mL in adjusted model; 95% CI, 1.05 to 1.27; P=0.003). Results were comparable across sex, race, diabetes mellitus, and prevalent and incident coronary heart disease subgroups. In participants with available left ventricular ejection fraction at HF diagnosis (265 of 341; 77.7%), association of resistin with HF risk was comparable for cases with reduced versus preserved ejection fraction.
Conclusions—Serum resistin concentrations are independently associated with risk for incident HF in older persons.
Key words: heart failure • elderly • resistin