on February 16, 2009
Published online before print February 16, 2009, doi: 10.1161/ATVBAHA.108.179788
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Submitted on December 12, 2008
Accepted on December 18, 2008
Thrombosis and Antithrombotic Therapy in Women
Alison L. Bailey ;
From the Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, VA Medical Center, Lexington.
* To whom correspondence should be addressed. E-mail: SusanSmyth{at}uky.edu.
Abstract—Sex-based differences in the prevalence and presentation of arterial and venous thrombosis exist, and emerging data indicate that men and women do not accrue equal benefit from antithrombotic therapy. Sex hormones alter procoagulant protein expression and the function of blood and vascular cells. Sex-based differences in platelet function have been reported, and in animal models, sex-based differences in thrombosis have been noted. Here we review plausible mechanisms that may explain how sex functions as a modifier of thrombosis and summarize clinical data on the interaction between sex and response to antithrombotic therapy.
Key words: anti-thrombotic therapy • female • platelet • thrombosis
Related Article:
- Cardiovascular Disease in Women
- Nigel Mackman and Susan Smyth
Arterioscler Thromb Vasc Biol 2009 29: 277-278.[Extract] [Full Text] [PDF]
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