on July 24, 2008
Published online before print July 24, 2008, doi: 10.1161/ATVBAHA.108.172015
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Submitted on January 30, 2008
Accepted on July 14, 2008
Integrins. The Keys to Unlocking Angiogenesis
Rita Silva ;
From the Adhesion and Angiogenesis Group, Centre for Tumour Biology, Cancer Research UK Clinical Centre and the Institute of Cancer, Barts & The London & Queen Mary's School of Medicine & Dentistry, John Vane Science Centre, Charterhouse Square, London UK.
* To whom correspondence should be addressed. E-mail: louise.reynolds{at}cancer.org.uk.
Abstract—Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.
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