on May 29, 2008
Published online before print May 29, 2008, doi: 10.1161/ATVBAHA.108.167346
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on January 21, 2008
Accepted on May 15, 2008
Femoral Plaques Confound the Association of Circulating Oxidized Low-Density Lipoprotein With Carotid Atherosclerosis in a General Population Aged 35 to 55 Years. The Asklepios Study
Michel R. Langlois *;
From the Department of Clinical Chemistry (M.L., V.B.), AZ St-Jan Hospital, Bruges; the Department of Cardiovascular Diseases (E.R., M.D.B., T.G.), Ghent University Hospital; the Department of Public Health (D.D.B., G.D.B.), Ghent University; and the Department of Molecular Biotechnology, Faculty of Bioscience Engineering (S.B.), Ghent University, Belgium.
* To whom correspondence should be addressed. E-mail: michel.langlois{at}azbrugge.be.
Objective—Reported associations of oxidized low-density lipoprotein (oxLDL) with noninvasive measures of atherosclerosis are inconsistent. In the Asklepios Study cohort of asymptomatic subjects aged 35 to 55 years, we evaluated the relationship of circulating oxLDL with subclinical atherosclerosis in the carotid and femoral arteries.
Methods and Results—Participants (n=2524, 51.5% females) completed a study questionnaire and underwent a clinical examination, blood analysis of oxLDL (mAb-4E6) and other risk markers, and ultrasound examination of intima-media thickness (IMT) and plaques in the left and right carotid and femoral arteries. oxLDL concentrations were highest in subjects with femoral plaques (n=658). In the group of subjects with carotid plaques (n=476), elevated oxLDL concentrations are related to concomitant femoral plaques detected in 54% of these subjects. Multivariate regression analyses (including anthropometric, hemodynamic, biochemical, and lifestyle variables) showed that femoral plaques are independently related to oxLDL whereas femoral IMT, carotid IMT, or carotid plaques were not independently associated with oxLDL.
Conclusion—Circulating oxLDL is independently associated with femoral plaque and not with carotid artery wall damage.
Key words: atherosclerosis • oxidized lipids • Doppler ultrasound • carotid arteries • peripheral vasculature
This article has been cited by other articles:
 |
|
 |
|
  T. De Meyer, E. R. Rietzschel, M. L. De Buyzere, M. R. Langlois, D. De Bacquer, P. Segers, P. Van Damme, G. G. De Backer, P. Van Oostveldt, W. Van Criekinge, et al. Systemic telomere length and preclinical atherosclerosis: the Asklepios Study Eur. Heart J., August 17, 2009; (2009) ehp324v1. [Abstract] [Full Text] [PDF]
|
|