on April 9, 2009
Published online before print April 9, 2009, doi: 10.1161/ATVBAHA.108.165530
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Submitted on January 14, 2009
Accepted on March 19, 2009
Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis
Farouc A. Jaffer *;
From the Donald W. Reynolds Cardiovascular Clinical Research Center (F.A.J., P.L., R.W.) Harvard Medical School; the Cardiovascular Research Center and Cardiology Division (F.A.J.), the Center for Molecular Imaging Research (F.A.J., R.W.), and the Center for Systems Biology (R.W.), Massachusetts General Hospital; and the Cardiovascular Division (P.L.), Brigham and Women';s Hospital, Boston, Mass.
* To whom correspondence should be addressed. E-mail: fjaffer{at}mgh.harvard.edu.
Abstract—Imaging approaches that visualize molecular targets rather than anatomic structures aim to illuminate vital molecular and cellular aspects of atherosclerosis biology in vivo. Several such molecular imaging strategies are poised for rapid clinical application. This review describes the growing role of in vivo optical molecular imaging in atherosclerosis and highlights its ability to visualize atheroma inflammation, calcification, and angiogenesis. In addition we discuss advances in multimodality probes, both in the context of multimodal imaging as well as multifunctional, or "theranostic," nanoparticles. This review highlights particular molecular imaging strategies that possess strong potential for clinical translation.
Key words: atherosclerosis • molecular imaging • optical • fluorescence • multimodality • nanoparticle
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