on January 3, 2008
Published online before print January 3, 2008, doi: 10.1161/ATVBAHA.107.158915
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Submitted on November 11, 2007
Accepted on December 19, 2007
Platelets: Inflammatory Firebugs of Vascular Walls
Andreas E. May *;
From the Medizinische Klinik III, Eberhard Karls Universität Tübingen, Germany.
* To whom correspondence should be addressed. E-mail: andreas.may{at}med.uni-tuebingen.de.
Abstract—Atherosclerosis is an inflammatory disease. Platelets can "inflame" the vascular wall by various mechanisms and thereby initiate and support the development of atherosclerosis. Platelet interaction with leukocytes, endothelial cells, and circulating progenitor cells triggers autocrine and paracrine activation processes, leading to inflammatory and atherogenic cascades at the vascular wall. This review highlights the molecular key components and pathways used by platelets to trigger and accelerate inflammation at the vascular wall and, thereby, atherosclerosis.
Key words: platelets • atherosclerosis • inflammation • vasculature • cardiovascular events
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