on December 27, 2007
Published online before print December 27, 2007, doi: 10.1161/ATVBAHA.107.158014
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Submitted on October 17, 2007
Accepted on December 1, 2007
VE-Cadherin. The Major Endothelial Adhesion Molecule Controlling Cellular Junctions and Blood Vessel Formation
Dietmar Vestweber *
From the Max-Planck-Institute of Molecular Biomedicine, Münster, Germany.
* To whom correspondence should be addressed. E-mail: vestweb{at}mpi-muenster.mpg.de.
Abstract—Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule located at junctions between endothelial cells. In analogy of the role of E-cadherin as major determinant for epithelial cell contact integrity, VE-cadherin is of vital importance for the maintenance and control of endothelial cell contacts. Mechanisms that regulate VE-cadherin–mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. This review will focus on recent new developments in understanding the role of VE-cadherin in controlling endothelial cell contacts and influencing endothelial cell behavior by various outside-in signaling processes.
Key words: vascular permeability • VE-cadherin • leukocyte extravasation • cell adhesion
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