Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
Published Online
on February 21, 2008

Arteriosclerosis, Thrombosis, and Vascular Biology. 2008
Published online before print February 21, 2008, doi: 10.1161/ATVBAHA.107.156596
A more recent version of this article appeared on May 1, 2008
This Article
Right arrow Full Text (PDF)
Right arrow Additional Materials
Right arrow All Versions of this Article:
28/5/961    most recent
ATVBAHA.107.156596v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leong, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leong, T.

Submitted on September 23, 2007
Accepted on February 11, 2008

Asymmetric Dimethylarginine Independently Predicts Fatal and Nonfatal Myocardial Infarction and Stroke in Women. 24-Year Follow-Up of the Population Study of Women in Gothenburg

Tora Leong ; Dimitri Zylberstein ; Ian Graham *; Lauren Lissner ; Deirdre Ward ; Jane Fogarty ; Calle Bengtsson ; Cecilia Björkelund ; Dag Thelle ; for The Swedish-Irish-Norwegian (SIN) Collaboration

From the Department of Cardiology (T.L., I.G., D.W.), Adelaide & Meath Hospital, Tallaght, Dublin, Ireland; the Department of Public Health and Community Medicine (D.Z., L.L., C. Bengtsson, C. Björkelund, D.T.), Institute of Medicine at the Sahlgrenska Academy, Göteborg University, Göteborg, Sweden; the Department of Clinical Chemistry (J.F.), Adelaide & Meath Hospital, Tallaght, Dublin, Ireland; and the University of Oslo (D.T.), Oslo, Norway.

* To whom correspondence should be addressed. E-mail: ian.graham{at}amnch.ie.

Objective—Asymmetrical dimethylarginine (ADMA) reduces nitric oxide by inhibiting nitric oxide synthase, and it is associated with cardiovascular disease (CVD). Our study examined the association of ADMA with CVD prospectively in a healthy population-based cohort of women.

Methods and Results—We measured baseline ADMA of 880 women in the Population Study of Women in Gothenburg using high-performance liquid chromatography. After adjustment for traditional risk factors, creatinine clearance, and homocysteine using Cox models, the HR (95% CI in parentheses) of CVD end points at 24 years for a 0.15 µmol/L (1 SD) increase in ADMA were: all-cause mortality 1.12 (0.96, 1.32), fatal CVD 1.30 (1.04, 1.62), total CVD events 1.29 (1.09, 1.53). The top quintile (ADMA ≥0.71 µmol/L) compared with the bottom four-fifths, conferred a cumulative risk 22 versus 14%, relative risk 1.75 (95% CI 1.18, 2.59) and population attributable risk 12.7% of total CVD events, and further identified individuals who are at higher than expected risk based on the SCORE and Framingham systems.

Conclusions—A 0.15 µmol/L increase in baseline ADMA levels is associated with approximately 30% increase in incident cardiovascular risk at 24 years in women after adjustment. ADMA levels ≥0.71 µmol/L enhances CVD risk assessment in women.
Key words: asymmetrical dimethylarginine • cardiovascular diseases • myocardial infarction • stroke • women




This article has been cited by other articles:


Home page
 StrokeHome page
A. Pikula, R. H. Boger, A. S. Beiser, R. Maas, C. DeCarli, E. Schwedhelm, J. J. Himali, F. Schulze, R. Au, M. Kelly-Hayes, et al.
Association of Plasma ADMA Levels With MRI Markers of Vascular Brain Injury: Framingham Offspring Study
Stroke, September 1, 2009; 40(9): 2959 - 2964.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
R. Maas, V. Xanthakis, J. F. Polak, E. Schwedhelm, L. M. Sullivan, R. Benndorf, F. Schulze, R. S. Vasan, P. A. Wolf, R. H. Boger, et al.
Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort
Stroke, August 1, 2009; 40(8): 2715 - 2719.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
J. M. Young, N. Terrin, X. Wang, T. Greene, G. J. Beck, J. W. Kusek, A. J. Collins, M. J. Sarnak, and V. Menon
Asymmetric Dimethylarginine and Mortality in Stages 3 to 4 Chronic Kidney Disease
Clin. J. Am. Soc. Nephrol., June 1, 2009; 4(6): 1115 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. H. Boger, L. M. Sullivan, E. Schwedhelm, T. J. Wang, R. Maas, E. J. Benjamin, F. Schulze, V. Xanthakis, R. A. Benndorf, and R. S. Vasan
Plasma Asymmetric Dimethylarginine and Incidence of Cardiovascular Disease and Death in the Community
Circulation, March 31, 2009; 119(12): 1592 - 1600.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. J. Nicholls, S. E. Nissen, S. L. Hazen, Z. Wang, R. Koeth, B. Levison, B. DelFraino, V. Dzavik, O. W. Griffith, D. Hathaway, et al.
Response to Letter Regarding Article, "Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarct"
Circulation, September 2, 2008; 118(10): e150 - e150.
[Full Text] [PDF]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2008 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.