on October 19, 2007
Published online before print October 19, 2007, doi: 10.1161/ATVBAHA.107.155317
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on September 3, 2007
Accepted on October 9, 2007
Cell-Based Therapy of Myocardial Infarction
Stefanie Dimmeler *;
From Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Germany.
* To whom correspondence should be addressed. E-mail: Dimmeler{at}em.uni-frankfurt.de.
Abstract—Cell-based therapy is a promising option for treatment of ischemic diseases. Several cell types have experimentally been shown to increase the functional recovery of the heart after ischemia by physically forming new blood vessels, differentiating to cardiac myocytes and—additionally or alternatively—by providing proangiogenic and antiapoptotic factors promoting tissue repair in a paracrine manner. Clinical studies preferentially used adult bone marrow–derived cells for the treatment of patients with acute myocardial infarction. Most of the studies suggested that cell therapy reduced the infarct size and improved cardiac contractile function. However, cell therapy is in its early stages, and various questions remain. For example, the identification of those patients who benefit most from cell therapy, the optimal cell type and number for patient with acute and chronic diseases, the best time and way of cell delivery, and the mechanisms of action by which cells exhibit beneficial effects, need to be further evaluated. Although no major safety concerns were raised during the initial clinical trials, several potential side effects need to be carefully monitored. The present review article summarizes the results of the clinical studies and discusses the open issues.
Key words: cell therapy • neovascularization • stem cells • acute myocardial infarction
This article has been cited by other articles:
 |
|
 |
|
  F. H. Seeger, T. Rasper, M. Koyanagi, H. Fox, A. M. Zeiher, and S. Dimmeler CXCR4 Expression Determines Functional Activity of Bone Marrow-Derived Mononuclear Cells for Therapeutic Neovascularization in Acute Ischemia Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1802 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Padin-Iruegas, Y. Misao, M. E. Davis, V. F.M. Segers, G. Esposito, T. Tokunou, K. Urbanek, T. Hosoda, M. Rota, P. Anversa, et al. Cardiac Progenitor Cells and Biotinylated Insulin-Like Growth Factor-1 Nanofibers Improve Endogenous and Exogenous Myocardial Regeneration After Infarction Circulation, September 8, 2009; 120(10): 876 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Dotsenko and M. Jahangiri Endogenous stem cells in patients undergoing coronary artery bypass graft surgery Eur. J. Cardiothorac. Surg., September 1, 2009; 36(3): 563 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Kraitchman and J. W.M. Bulte In Vivo Imaging of Stem Cells and Beta Cells Using Direct Cell Labeling and Reporter Gene Methods Arterioscler Thromb Vasc Biol, July 1, 2009; 29(7): 1025 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tendera, W. Wojakowski, W. Ruzyllo, L. Chojnowska, C. Kepka, W. Tracz, P. Musialek, W. Piwowarska, J. Nessler, P. Buszman, et al. Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial Eur. Heart J., June 1, 2009; 30(11): 1313 - 1321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P Sieveking and M. K. Ng Cell therapies for therapeutic angiogenesis: back to the bench Vascular Medicine, May 1, 2009; 14(2): 153 - 166. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Wisel, M. Khan, M. L. Kuppusamy, I. K. Mohan, S. M. Chacko, B. K. Rivera, B. C. Sun, K. Hideg, and P. Kuppusamy Pharmacological Preconditioning of Mesenchymal Stem Cells with Trimetazidine (1-[2,3,4-Trimethoxybenzyl]piperazine) Protects Hypoxic Cells against Oxidative Stress and Enhances Recovery of Myocardial Function in Infarcted Heart through Bcl-2 Expression J. Pharmacol. Exp. Ther., May 1, 2009; 329(2): 543 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lee, M. A. Stagg, S. Fukushima, G. K. R. Soppa, U. Siedlecka, S. J. Youssef, K. Suzuki, M. H. Yacoub, and C. M. N. Terracciano Adult progenitor cell transplantation influences contractile performance and calcium handling of recipient cardiomyocytes Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H927 - H936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tendera and W. Wojakowski Cell therapy--success does not come easy Eur. Heart J., March 2, 2009; 30(6): 640 - 641. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ausoni and S. Sartore From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration J. Cell Biol., February 9, 2009; 184(3): 357 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L Kao, W. Browder, and C. Li Cellular Cardiomyoplasty: What Have We Learned? Asian Cardiovasc Thorac Ann, January 1, 2009; 17(1): 89 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dimmeler and M. Tjwa Better Regenerative Output After Cellular Input: Healing Hearts by Combining Basic Fibroblast Factor and Cell-Based Therapy J. Am. Coll. Cardiol., December 2, 2008; 52(23): 1866 - 1868. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ruel, A. F.R. Stewart, and E. J. Suuronen From Genes to Regenerative Medicine: Approaches in Development Circ. Res., November 7, 2008; 103(10): 1050 - 1052. [Full Text] [PDF]
|
|
|
|
|
|
K. K. Hirschi, D. A. Ingram, and M. C. Yoder Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells Arterioscler Thromb Vasc Biol, September 1, 2008; 28(9): 1584 - 1595. [Full Text] [PDF]
|
|
|
|
|
|
P. Tossios, B. Krausgrill, M. Schmidt, T. Fischer, M. Halbach, J. W.U. Fries, S. Fahnenstich, P. Frommolt, I. Heppelmann, A. Schmidt, et al. Role of balloon occlusion for mononuclear bone marrow cell deposition after intracoronary injection in pigs with reperfused myocardial infarction Eur. Heart J., August 1, 2008; 29(15): 1911 - 1921. [Abstract] [Full Text] [PDF]
|
|