on January 3, 2008
Published online before print January 3, 2008, doi: 10.1161/ATVBAHA.107.155010
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Submitted on July 10, 2007
Accepted on December 15, 2007
Association Between Cardiovascular Risk Profiles and the Presence and Extent of Different Types of Coronary Atherosclerotic Plaque as Detected by Multidetector Computed Tomography
Fabian Bamberg ;
From the Cardiac MR PET CT Program (F.B., N.D., M.D.S., S.K.S., M.F., J.B., K.N., R.C.C., A.T., S.A., T.J.B., U.H.), the Department of Radiology (F.B., N.D., M.D.S., S.K.S., M.F., J.B., K.N., R.C.C., T.J.B., U.H.) and Cardiology Division (A.T.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; Harvard School of Public Health (F.B., U.H.), Boston Mass; the Department of Cardiology (W.K.), University of Ulm, Germany; and tge Department of Cardiology (S.A.), University of Erlangen, Germany.
* To whom correspondence should be addressed. E-mail: uhoffmann{at}partners.org.
Objective—To assess the association between cardiovascular risk factors and extent of noncalcified- (NCAP), mixed- (MCAP), and calcified coronary atherosclerotic plaque (CAP).
Methods and Results—In this cross-sectional study, we included consecutive subjects who presented with chest pain but had no history of coronary artery disease (CAD) and did not develop acute coronary syndrome. Contrast-enhanced 64-slice coronary MDCT was performed to determine the presence of NCAP, MCAP, and CAP for each coronary segment. Among 195 patients (91 women, mean age: 54.6±12.0) exclusively NCAP was detected in 11 patients (5.6%). The extent of NCAP decreased and the extent of MCAP and CAP increased with age (P=0.06, P=0.02, and P=0.13, respectively). Hyperlipidemia and family history of CAD were associated with the extent of NCAP after adjusting for other risk factors (P=0.02 and P=0.04, respectively) or for the extent of MCAP and CAP (P=0.02 and P=0.05, respectively).
Conclusions—Our data suggest that only a small proportion of individuals have exclusively NCAP and indicate that the relation of NCAP and CAP changes with age. Among individual risk factors, hyperlipidemia and family history of CAD may be associated with the extent of NCAP. Larger observational trials are necessary to confirm our findings.
Key words: tomography • atherosclerosis • imaging
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