on July 12, 2007
Published online before print July 12, 2007, doi: 10.1161/ATVBAHA.107.149484
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Submitted on June 7, 2007
Accepted on June 28, 2007
Interleukin-18, the Metabolic Syndrome, and Subclinical Atherosclerosis. Results From the Dallas Heart Study
Andreas Zirlik *;
From the Donald W. Reynolds Centers of the Brigham and Women’s Hospital (A.Z., N.G., L.M., P.L.), Harvard Medical School, Boston, Mass; and the University of Texas Southwestern Medical Center (S.A., A.K., D.K.M., G.L.V., S.G., J.d.L.), Dallas. Current affiliations: Department of Cardiology (A.Z.), University of Freiburg, Germany; Karolinska Institute (N.G.), Stockholm, Sweden; and Cardiovascular Disease (U.S.), Boehringer Ingelheim Pharmaceuticals, Ridgefield, Conn.
* To whom correspondence should be addressed. E-mail: andreas.zirlik{at}uniklinik-freiburg.de.
Objective--Although IL-18 promotes atherogenesis in animal studies and predicts cardiovascular risk in humans, it is unknown whether elevated IL-18 levels are associated with coronary atherosclerosis in the general population.
Methods and Results--IL-18 plasma levels were determined by ELISA in 2231 subjects from the Dallas Heart Study. In univariable analysis, IL-18 levels associated with traditional cardiovascular risk factors and particularly with components of the metabolic syndrome (MS, P<0.01 for trend across the number of MS components); IL-18 also associated with coronary artery calcium (CAC) scores measured by electron beam computed tomography and aortic plaque measured by MRI (P<0.01 for each). In multivariable analyses, IL-18 remained associated with multiple components of the MS but not with CAC or aortic plaque.
Conclusions--In a large population-based sample, elevated IL-18 plasma levels associated with risk factors for atherosclerosis and with the metabolic syndrome. The association between IL-18 and atherosclerosis diminished after accounting for traditional cardiovascular risk factors. These data suggest that IL-18 does not add independently to detection of atherosclerotic burden in asymptomatic individuals. (Arterioscler Thromb Vasc Biol. 2007;27;000-000.)
Key words: atherosclerosis • imaging • interleukins • risk factors • metabolic syndrome
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