on August 2, 2007
Arteriosclerosis, Thrombosis, and Vascular Biology. 2007
Published online before print August 2, 2007, doi: 10.1161/ATVBAHA.107.149179
Published online before print August 2, 2007, doi: 10.1161/ATVBAHA.107.149179
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Submitted on June 4, 2007
Accepted on July 20, 2007
Vascular Adhesion Molecules in Atherosclerosis
Elena Galkina and Klaus Ley *
From the Department of Biomedical Engineering and Robert M. Berne Cardiovascular Research Center, University of Virginia, Health Sciences Center, Charlottesville, Va.
* To whom correspondence should be addressed. E-mail: klausley{at}virginia.edu.
Abstract—Numerous reports document the role of vascular adhesion molecules in the development and progression of atherosclerosis. Recent novel findings in the field of adhesion molecules require an updated summary of current research. In this review, we highlight the role of vascular adhesion molecules including selectins, vascular cell adhesion molecule (VCAM)-1, intercellular adhesion molecule1 (ICAM-1), PECAM-1, JAMs, and connexins in atherosclerosis. The immune system is important in atherosclerosis, and significant efforts are under way to understand the vascular adhesion molecule–dependent mechanisms of immune cell trafficking into healthy and atherosclerosis-prone arterial walls. This review focuses on the role of vascular adhesion molecules in the regulation of immune cell homing during atherosclerosis and discusses future directions that will lead to better understanding of this disease.
Key words: atherosclerosis • pathophysiology • lymphocyte • leukocyte • monocyte • macrophages • trafficking
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