on July 5, 2007
Published online before print July 5, 2007, doi: 10.1161/ATVBAHA.107.147694
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Submitted on June 6, 2007
Accepted on June 27, 2007
JAM Family and Related Proteins in Leukocyte Migration
Paul F. Bradfield ;
From the Department of Pathology and Immunology (P.F.B., M.A.-L., B.A.I.), University Medical Centre, Geneva, Switzerland; and the Cardiovascular Medicine Unit (S.N.), National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom.
* To whom correspondence should be addressed. E-mail: beat.imhof{at}medecine.unige.ch.
Abstract--Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particular, recent research has focused on JAM subfamily members JAM-A, -B, and -C with newly described roles in leukocyte trafficking during inflammation and angiogenesis. However, research on all JAM family members has demonstrated recurring themes with striking similarities in the many diverse processes they are now known to regulate.
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