on June 21, 2007
Published online before print June 21, 2007, doi: 10.1161/ATVBAHA.107.145821
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Submitted on April 10, 2007
Accepted on May 27, 2007
Endothelial Signaling by Ig-Like Cell Adhesion Molecules
Jaap D. van Buul ;
From the Department of Molecular Cell Biology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.
* To whom correspondence should be addressed. E-mail: p.hordijk{at}sanquin.nl.
Abstract--The migration of leukocytes across the endothelial lining of the vascular wall requires a complicated series of adhesion and signaling events. Endothelial Ig-like cell adhesion molecules (IgCAMs) such as intercellular adhesion molecule-1 play an important role, not only as ligands for leukocyte integrins, but also as signaling initiators. Clustering these IgCAMs triggers a wide range of events in the endothelial cells’ interior, of which activation of Rho-like GTPases, induction of cytoskeletal changes, and the transient modulation of cell-cell contact are key events. This review discusses recent insights into this IgCAM-driven endothelial signaling and its consequences for leukocyte transendothelial migration.
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