on June 28, 2007
Published online before print June 28, 2007, doi: 10.1161/ATVBAHA.107.142810
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Submitted on February 22, 2007
Accepted on June 7, 2007
Murine Models of Vascular Thrombosis
Randal J. Westrick *;
From the Departments of Human Genetics (R.W.), Internal Medicine (M.W.), and the Division of Cardiology (D.E.), University of Michigan Medical Center, Ann Arbor.
* To whom correspondence should be addressed. E-mail: westricr{at}umich.edu.
Abstract--Thrombotic complications of vascular disease are the leading cause of morbidity and mortality in most industrialized countries. Despite this, safe and effective drugs targeting these complications are limited, especially in the chronic setting. This is because of the complexity of thrombosis in both arteries and veins, which is becoming increasingly evident as numerous factors are now known to affect the fate of a forming thrombus. To fully characterize thrombus formation in these settings, in vivo models are necessary to study the various components and intricate interactions that are involved. Genetic manipulations in mice are greatly facilitating the dissection of relevant pro- and antithrombotic influences. Standardized models for the study of thrombosis in mice as well as evolving techniques that allow imaging of molecular events during thrombus formation are now available. This review will highlight some of the recent developments in the field of thrombosis using mouse models and how these studies are expanding our knowledge of thrombotic disease.
Key words: animal models • thrombosis • vascular biology • atherosclerosis • mouse strains
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