Arteriosclerosis, Thrombosis, and Vascular Biology. 1984;4:97-102
Arteriosclerosis, Vol 4, 97-102, Copyright © 1984 by American Heart Association
ARTICLES |
Human apolipoprotein A-I--C-III gene complex is located on chromosome 11
GA Bruns, SK Karathanasis and JL Breslow
The genes for two of the apolipoproteins, apo A-I and apo C-III, previously shown to be within 3kb in the genome, were localized to human chromosome 11 by Southern blot analysis of DNA from human-rodent somatic cell hybrids. These two genes were shown to exhibit polymorphisms associated with dyslipoproteinemia and premature atherosclerosis, and it will now be possible to examine the relationship of these genes to the many others that have been assigned to this chromosome.
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