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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:1050.)
© 2008 American Heart Association, Inc.

Brief Reviews

Regulation of Macrophage Functions by PPAR-, PPAR-, and LXRs in Mice and Men

Elena Rigamonti; Giulia Chinetti-Gbaguidi; Bart Staels

From the Institut Pasteur de Lille, Inserm, U545, and Université de Lille 2, Faculté de Pharmacie et de Médecine, Lille, France.

Correspondence to Bart Staels, UR 545 INSERM, Institut Pasteur de Lille, 1, rue Calmette BP245, 59019 Lille, France. E-mail bart.staels{at}pasteur-lille.fr

Series Editor: Marja-Riitta Taskinen
Metabolic Syndrome and Atherosclerosis
ATVB In Focus

Preview Brief Reviews in this Series:

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•Barter PJ, Rye KA. Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome. Arteroscler Thromb Vasc Biol. 2008;28:39–46.
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Peroxisome proliferator-activated receptors (PPARs) and (liver X receptors) LXRs are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflammatory response. Because the macrophage plays an important role in host defense and immunoinflammatory pathologies, particular attention has been paid to the role of PPARs and LXRs in the control of macrophage gene expression and function. Research over the last few years has revealed important roles for PPAR-, PPAR-, and LXRs in macrophage inflammation and cholesterol homeostasis with consequences for atherosclerosis development. In this review we will discuss the role of these transcription factors in the control of macrophage activities, with particular attention to species-differences in macrophage function control by PPARs and LXR between rodents and humans.

Key Words: nuclear receptors • atherosclerosis • lipid metabolism • inflammation

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