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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:1703.)
© 2008 American Heart Association, Inc.

Brief Reviews

Integrins

The Keys to Unlocking Angiogenesis

Rita Silva; Gabriela D'Amico; Kairbaan M. Hodivala-Dilke; Louise E. Reynolds

From the Adhesion and Angiogenesis Group, Centre for Tumour Biology, Cancer Research UK Clinical Centre and the Institute of Cancer, Barts & The London & Queen Mary’s School of Medicine & Dentistry, John Vane Science Centre, Charterhouse Square, London UK.

Correspondence to Louise Reynolds, Cancer Research UK, Charterhouse Square, London EC1M 6BQ, UK. E-mail louise.reynolds{at}cancer.org.uk

Series Editor: Dietmar Vestweber
Vascular Adhesion Molecules
ATVB In Focus

Preview Brief Reviews in this Series:

•van Buul JD, Kanters E, and Hordijk PL. Endothelial signaling by Ig-like cell adhesion molecules. Arterioscler Thromb Vasc Biol. 2007;27:1870–1876.
•Bradfield PF, Nourshargh S, Aurrand-Lions M, Imhof BA. JAM family and related proteins in leukocyte migration. Arterioscler Thromb Vasc Biol. 2007;27:2104–2112.
•Galkina E and Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol. 2007;27: 2292–2301.
•Jalkanen S, Salmi M. VAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation. Arterioscler Thromb Vasc Biol. 2008;28:18–26.
•Vestweber, D. VE-cadharin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 2008;28:223–232.
•Varga-Szabo D, Pleines I, Nieswandt B. Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol. 2008:28:403–412.

Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.

Key Words: integrins • endothelial cells • pericytes • angiogenesis • antiangiogenic therapies

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