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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:1248.)
© 2007 American Heart Association, Inc.

Brief Reviews

Developmental Basis of Vascular Smooth Muscle Diversity

Mark W. Majesky

From the Departments of Medicine & Genetics, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill.

Correspondence to Mark W. Majesky, Departments of Medicine & Genetics, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599-7126. E-mail mmajesky{at}med.unc.edu

The origins of vascular smooth muscle are far more diverse than previously thought. Lineage mapping studies show that the segmental organization of early vertebrate embryos leaves footprints on the adult vascular system in the form of a mosaic pattern of different smooth muscle types. Moreover, evolutionarily conserved tissue forming pathways produce vascular smooth muscle from a variety of unanticipated sources. A closer look at the diversity of smooth muscle origins in vascular development provides new perspectives about how blood vessels differ from one another and why they respond in disparate ways to common risk factors associated with vascular disease.

The origins of vascular smooth muscle are far more diverse than previously thought. A closer look at the diversity of smooth muscle origins in vascular development provides new perspectives about how blood vessels differ from one another and why they respond in disparate ways to common risk factors associated with vascular disease.

Key Words: vascular development • embryo • lineage • serum response factor • heterogeneity

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