This Article Full Text Full Text (PDF) All Versions of this Article: 27/2/352    most recent 01.ATV.0000254150.97741.fev1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jenny, N. S. Articles by Psaty, B. M. Search for Related Content PubMed PubMed Citation Articles by Jenny, N. S. Articles by Psaty, B. M. Pubmed/NCBI databases Gene GEO Profiles HomoloGene Nucleotide Protein UniGene Substance via MeSH Medline Plus Health Information Seniors' Health Related Collections Risk Factors Related Article

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:352.)
© 2007 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Serum Amyloid P and Cardiovascular Disease in Older Men and Women

Results from the Cardiovascular Health Study

Nancy Swords Jenny; Alice M. Arnold; Lewis H. Kuller; Russell P. Tracy; Bruce M. Psaty

From the Department of Pathology (N.S.J.), College of Medicine, University of Vermont, Burlington; the Department of Biostatistics (A.M.A.), University of Washington, Seattle; the Department of Epidemiology (L.H.K.), University of Pittsburgh School of Public Health, Pa; the Department of Biochemistry (R.P.T.), University of Vermont, Burlington; and the Departments of Medicine, Epidemiology, and Health Services (B.M.P.), Cardiovascular Health Research Unit, University of Washington, Seattle.

Correspondence to Nancy Swords Jenny, PhD, Department of Pathology, College of Medicine, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446. E-mail Nancy.Jenny{at}uvm.edu

Objective— Serum amyloid P (SAP), a pentraxin like C-reactive protein (CRP), functions in innate immunity. However, associations of SAP with cardiovascular disease (CVD) are unknown.

Methods and Results— We examined these associations in the Cardiovascular Health Study using a case–cohort design. Nonexclusive case groups were incident angina (n=523), myocardial infarction (MI; n=308), stroke (n=323), and CVD death (n=288). 786 participants had no events. SAP was correlated with CRP, CVD risk factors (obesity, blood pressure, lipids), common and internal carotid wall thickness, and ankle-brachial index (all P<0.02). In Cox regression models adjusted for age, sex, and ethnicity, a standard deviation increase in SAP (9.8 mg/L) was associated with angina (hazard ratio; 95% confidence interval 1.3; 1.2 to 1.5) and MI (1.3; 1.1 to 1.5), but not stroke (1.1; 0.9 to 1.3) or CVD death (1.1; 0.9 to 1.3). Adding CRP to the models had no significant effect on associations. Adjusting for CVD risk factors slightly attenuated SAP associations with CVD events; however, associations with angina and MI remained significant.

Conclusions— Although both are pentraxins, SAP and CRP may represent different facets of inflammation. The association of SAP with CVD in these older adults further supports the role of innate immunity in atherosclerosis.

Serum amyloid P (SAP) is a pentraxin similar to C-reactive protein. We examined the association of SAP with cardiovascular disease (CVD) in older adults. SAP was associated with inflammatory markers, CVD risk factors, measures of subclinical CVD, and incident angina and MI.

Key Words: cardiovascular disease • serum amyloid P • C-reactive protein • elderly • atherosclerosis

Related Article:

Serum Amyloid P Component and Cardiovascular Disease: Is There a Sensible Link?

Wolfgang Koenig
Arterioscler. Thromb. Vasc. Biol. 2007 27: 698-700. [Full Text] [PDF]

This article has been cited by other articles:

				C. R. Stewart, A. Haw III, R. Lopez, T. O. McDonald, J. M. Callaghan, M. J. McConville, K. J. Moore, G. J. Howlett, and K. D. O'Brien Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications J. Lipid Res., October 1, 2007; 48(10): 2162 - 2171. [Abstract] [Full Text] [PDF]

				W. Koenig Serum Amyloid P Component and Cardiovascular Disease: Is There a Sensible Link? Arterioscler. Thromb. Vasc. Biol., April 1, 2007; 27(4): 698 - 700. [Full Text] [PDF]