Published online before print August 2, 2007, doi: 10.1161/ATVBAHA.107.149179
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2007 American Heart Association, Inc.
Brief Reviews |
Vascular Adhesion Molecules in Atherosclerosis
From the Department of Biomedical Engineering and Robert M. Berne Cardiovascular Research Center, University of Virginia, Health Sciences Center, Charlottesville, Va.
Correspondence to Klaus Ley, Robert M. Berne Cardiovascular Research Center, University of Virginia, P.O. Box 801394, Charlottesville, VA 22908. E-mail klausley{at}virginia.edu
Series Editor: Dietmar Vestweber Previous Brief Reviews in this Series:
•van Buul JD, Kanters E, and Hordijk PL. Endothelial signaling by Ig-like cell adhesion molecules. Atheroscler Thromb Vasc Biol. 2007;27:1870–1876.
•Bradfield PF, Nourshargh S, Aurrand-Lions M, Imhof BA. JAM family and related proteins in leukocyte migration. Atheroscler Thromb Vasc Biol. 2007;27:2104–2112.
Numerous reports document the role of vascular adhesion molecules in the development and progression of atherosclerosis. Recent novel findings in the field of adhesion molecules require an updated summary of current research. In this review, we highlight the role of vascular adhesion molecules including selectins, vascular cell adhesion molecule (VCAM)-1, intercellular adhesion molecule1 (ICAM-1), PECAM-1, JAMs, and connexins in atherosclerosis. The immune system is important in atherosclerosis, and significant efforts are under way to understand the vascular adhesion molecule–dependent mechanisms of immune cell trafficking into healthy and atherosclerosis-prone arterial walls. This review focuses on the role of vascular adhesion molecules in the regulation of immune cell homing during atherosclerosis and discusses future directions that will lead to better understanding of this disease.
Leukocyte and endothelial adhesion molecules play key roles in the development and progression of atherosclerosis. In animal models, blocking or eliminating P-selectin, VCAM-1 or 
4β1 integrin reduces atherosclerotic lesion formation by more than 50%. Smaller effects are seen by manipulating E-selectin, ICAM-1 or the JAM family of adhesion molecules.
Key Words: atherosclerosis • pathophysiology • lymphocyte • leukocyte • monocyte • macrophages • trafficking
This article has been cited by other articles:
 |
|
 |
|
  E. Koltsova and K. Ley Tyrosine Sulfation of Leukocyte Adhesion Molecules and Chemokine Receptors Promotes Atherosclerosis Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1709 - 1711. [Full Text] [PDF]
|
|
|
|
|
|
A. D. Westmuckett and K. L. Moore Lack of Tyrosylprotein Sulfotransferase Activity in Hematopoietic Cells Drastically Attenuates Atherosclerosis in Ldlr-/- Mice Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1730 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. K. Swirski, R. Weissleder, and M. J. Pittet Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis Arterioscler Thromb Vasc Biol, October 1, 2009; 29(10): 1424 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-N. Zhang, J. Vincelette, Y. Cheng, U. Mehra, D. Chen, S.-K. Anandan, R. Gless, H. K. Webb, and Y.-X. Wang Inhibition of Soluble Epoxide Hydrolase Attenuated Atherosclerosis, Abdominal Aortic Aneurysm Formation, and Dyslipidemia Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1265 - 1270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, E. J. Barrett, S.-H. Ko, W. Cao, and Z. Liu Insulin and Insulin-Like Growth Factor-I Receptors Differentially Mediate Insulin-Stimulated Adhesion Molecule Production by Endothelial Cells Endocrinology, August 1, 2009; 150(8): 3475 - 3482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Thurberg, J. T. Fallon, R. Mitchell, T. Aretz, R. E. Gordon, and M. W. O'Callaghan Cardiac Microvascular Pathology in Fabry Disease: Evaluation of Endomyocardial Biopsies Before and After Enzyme Replacement Therapy Circulation, May 19, 2009; 119(19): 2561 - 2567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. CELLA, F. VIANELLO, F. COZZI, H. MAROTTA, F. TONA, G. SAGGIORATO, O. IQBAL, and J. FAREED Effect of Bosentan on Plasma Markers of Endothelial Cell Activity in Patients with Secondary Pulmonary Hypertension Related to Connective Tissue Diseases J Rheumatol, April 1, 2009; 36(4): 760 - 767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Nold-Petry, M. F. Nold, J. A. Zepp, S.-H. Kim, N. F. Voelkel, and C. A. Dinarello IL-32-dependent effects of IL-1{beta} on endothelial cell functions PNAS, March 10, 2009; 106(10): 3883 - 3888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Rajapakse, X.-F. Ming, J. M. Carvas, and Z. Yang The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H815 - H822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Goel, B. R. Schrank, S. Arora, B. Boylan, B. Fleming, H. Miura, P. J. Newman, R. C. Molthen, and D. K. Newman Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor-Deficient Mice Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 1996 - 2002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Gleissner, P. von Hundelshausen, and K. Ley Platelet Chemokines in Vascular Disease Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 1920 - 1927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Smedlund and G. Vazquez Involvement of Native TRPC3 Proteins in ATP-Dependent Expression of VCAM-1 and Monocyte Adherence in Coronary Artery Endothelial Cells Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 2049 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kisucka, A. K. Chauhan, I. S. Patten, A. Yesilaltay, C. Neumann, R. A. Van Etten, M. Krieger, and D. D. Wagner Peroxiredoxin1 Prevents Excessive Endothelial Activation and Early Atherosclerosis Circ. Res., September 12, 2008; 103(6): 598 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Orasanu, O. Ziouzenkova, P. R. Devchand, V. Nehra, O. Hamdy, E. S. Horton, and J. Plutzky The Peroxisome Proliferator-Activated Receptor-{gamma} Agonist Pioglitazone Represses Inflammation in a Peroxisome Proliferator-Activated Receptor-{alpha}-Dependent Manner In Vitro and In Vivo in Mice J. Am. Coll. Cardiol., September 2, 2008; 52(10): 869 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Frank and M. P. Lisanti ICAM-1: role in inflammation and in the regulation of vascular permeability Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H926 - H927. [Full Text] [PDF]
|
|
|
|
|
|
R. M. Mansouri, E. Bauge, B. Staels, and P. Gervois Systemic and Distal Repercussions of Liver-Specific Peroxisome Proliferator-Activated Receptor-{alpha} Control of the Acute-Phase Response Endocrinology, June 1, 2008; 149(6): 3215 - 3223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Hettema, H. Bootsma, and C. G. M. Kallenberg Macrovascular disease and atherosclerosis in SSc Rheumatology, May 1, 2008; 47(5): 578 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Montecucco, F. Burger, F. Mach, and S. Steffens CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1145 - H1155. [Abstract] [Full Text] [PDF]
|
|