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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:2104.)
© 2007 American Heart Association, Inc.

Brief Reviews

JAM Family and Related Proteins in Leukocyte Migration (Vestweber Series)

Paul F. Bradfield; Sussan Nourshargh; Michel Aurrand-Lions; Beat A. Imhof

From the Department of Pathology and Immunology (P.F.B., M.A.-L., B.A.I.), University Medical Centre, Geneva, Switzerland; and the Cardiovascular Medicine Unit (S.N.), National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom.

Correspondence to Beat A Imhof, University Medical Centre, 1 Rue Michel-Servet, CH-1211, Geneva 4, Switzerland. E-mail beat.imhof{at}medecine.unige.ch

Series Editor: Dietmar Vestweber
Vascular Adhesion Molecules
ATVB In Focus

Previous Brief Reviews in this Series:

•Vestweber D. Vascular adhesion molecules. 2007;27:1869.
•van Buul K, Kanters E, and Hordijk P. Endothelial signaling by Ig-like cell adhesion molecules. 2007;27:1870–1876.
•Coggins M and Bloch K. Nitric oxide in the pulmonary vasculature. 2007;27:1887–1885.
•Shirk R and Vlasuk G. Inhibitors of factor VIIa/Tissue factor. 2007;27:1895–1900.
•Desch K and Motto D. Thrombotic thrombocytopenic purpura in humans and mice. 2007;27:1901–1908.

Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particular, recent research has focused on JAM subfamily members JAM-A, -B, and -C with newly described roles in leukocyte trafficking during inflammation and angiogenesis. However, research on all JAM family members has demonstrated recurring themes with striking similarities in the many diverse processes they are now known to regulate.

Key Words: endothelium • leukocyte • transmigration • inflammation

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