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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:2079.)
© 2007 American Heart Association, Inc.

Brief Reviews

Murine Models of Vascular Thrombosis

Randal J. Westrick; Mary E. Winn; Daniel T. Eitzman

From the Departments of Human Genetics (R.W.), Internal Medicine (M.W.), and the Division of Cardiology (D.E.), University of Michigan Medical Center, Ann Arbor.

Correspondence to Randal J. Westrick, University of Michigan, 5214 LSI Building, 210 Washtenaw Avenue, Ann Arbor, MI 48109. E-mail westricr{at}umich.edu

Series Editor: Daniel T. Eitzman
Regulation of Hemostasis and Thrombosis: Insights from Murine Models
ATVB In Focus

Previous Brief Reviews in this Series:

•Eitzman D. Regulation of hemostasis and thrombosis: insights from murine models. 2007;27:453.
•Tollefsen D. Heparin cofactor II modulates the response to vascular injury. 2007;27:454–460.
•Fay WP, Garg N, and Sunkar M. Vascular function of the plasminogen activation system. 2007;28:1231–1237.

Thrombotic complications of vascular disease are the leading cause of morbidity and mortality in most industrialized countries. Despite this, safe and effective drugs targeting these complications are limited, especially in the chronic setting. This is because of the complexity of thrombosis in both arteries and veins, which is becoming increasingly evident as numerous factors are now known to affect the fate of a forming thrombus. To fully characterize thrombus formation in these settings, in vivo models are necessary to study the various components and intricate interactions that are involved. Genetic manipulations in mice are greatly facilitating the dissection of relevant pro- and antithrombotic influences. Standardized models for the study of thrombosis in mice as well as evolving techniques that allow imaging of molecular events during thrombus formation are now available. This review will highlight some of the recent developments in the field of thrombosis using mouse models and how these studies are expanding our knowledge of thrombotic disease.

Thrombotic complications of vascular disease remain a leading cause of mortality worldwide. Effective chronic treatment strategies are limited in part because of an inadequate understanding of the factors that influence thrombosis. This review focuses on models of thrombosis useful for elucidating important regulators of thrombosis in mice.

Key Words: animal models • thrombosis • vascular biology • atherosclerosis • mouse strains

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