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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:37.)
© 2007 American Heart Association, Inc.

Brief Reviews

The Vasohibin Family

A Negative Regulatory System of Angiogenesis Genetically Programmed in Endothelial Cells

Yasufumi Sato; Hikaru Sonoda

From the Department of Vascular Biology (Y.S.), Institute of Development, Aging, and Cancer, Tohoku University, Sendai, and the Discovery Research Laboratories (H.S.), Shionogi & Co Ltd, Osaka, Japan.

Correspondence to Yasufumi Sato, Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. E-mail y-sato{at}idac.tohoku.ac.jp

Biological phenomena are under the precise control by the genome. For the regulation of angiogenesis, proangiogenic genes such as VEGFs and angiopoietins are highly conserved, act specifically on endothelial cells, and play a fundamental role. In this sense, nature should prepare specific antiangiogenic genes as well. However, this counterpart of genomic regulation of angiogenesis remains to be established. We recently isolated a novel endothelium-derived angiogenesis inhibitor and named it vasohibin. Vasohibin is dominantly expressed in endothelial cells, induced by the stimulation with VEGF or FGF-2, and selectively affects on endothelial cells and inhibits angiogenesis. Although the mechanism of how vasohibin inhibits angiogenesis remains to be elucidated, our discovery of vasohibin as an endothelium-derived VEGF-inducible angiogenesis inhibitor should shed light on the genomic basis of the negative regulation of angiogenesis.

Genomic regulation of angiogenesis inhibition remains to be established. We recently isolated a novel endothelium-derived angiogenesis inhibitor and named it vasohibin. Our discovery of vasohibin as an endothelium-derived VEGF-inducible angiogenesis inhibitor should shed light on the genomic basis of he negative regulation of angiogenesis.

Key Words: endothelial cell • angiogenesis inhibitor • VEGF • negative feedback

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