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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:1674.)
© 2006 American Heart Association, Inc.

Thrombosis

Dietary Factors Related to Higher Plasma Fibrinogen Levels of Japanese-Americans in Hawaii Compared With Japanese in Japan

Katsuyuki Miura; Hideaki Nakagawa; Hirotsugu Ueshima; Akira Okayama; Shigeyuki Saitoh; J. David Curb; Beatriz L. Rodriguez; Kiyomi Sakata; Nagako Okuda; Katsushi Yoshita; Jeremiah Stamler for the INTERMAP and INTERLIPID Research Groups

From the Department of Epidemiology and Public Health (K.M., H.N.), Kanazawa Medical University, Ishikawa, Japan; Department of Health Science (H.U., N.O.), Shiga University of Medical Science, Otsu, Japan; Department of Preventive Cardiology (A.O.), National Cardiovascular Center, Osaka, Japan; Second Department of Internal Medicine (S.S.), Sapporo Medical University, Japan; Pacific Health Research Institute (J.D.C., B.L.R.), Honolulu, Hawaii; Department of Hygiene and Preventive Medicine (K.S.), Iwate Medical University, Morioka, Japan; Division of Health and Nutrition Monitoring (K.Y.), National Institute of Health and Nutrition, Tokyo, Japan; and Department of Preventive Medicine (J.S.), Feinberg School of Medicine, Northwestern University, Chicago, Ill.

Reprint requests to Katsuyuki Miura, MD, PhD, Department of Epidemiology and Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan. E-mail miura{at}kanazawa-med.ac.jp

Objective— We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan.

Methods and Results— Plasma fibrinogen and nutrient intakes were examined by standardized methods in men and women 40 to 59 years of age from a Japanese-American sample in Hawaii (100 men and 106 women) and 4 population samples in Japan (569 men and 567 women). Multiple linear regression models were used to examine the relationship between dietary factors and the plasma fibrinogen difference between Hawaii and Japan. Average plasma fibrinogen was significantly higher in Hawaii compared with Japan (P<0.001 in both genders). In multiple linear regression analyses with each dietary variable considered separately, body mass index reduced the plasma fibrinogen difference between Hawaii and Japan by 20.4%; iron intake (mg/1000 kcal) and estimated total sugar intake (%kcal) reduced this difference by 30.0% and 14.4%, respectively. In a model that included body mass index, iron, estimated total sugars, and caffeine (also age and gender), this difference was reduced by 61.3% (from 42.2 to 16.3 mg/dL).

Conclusions— Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle.

We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan. Data from this epidemiologic study indicate that higher intakes of iron, sugar, and caffeine, plus obesity, account largely for higher fibrinogen levels with Westernized lifestyle.

Key Words: fibrinogen • nutrition • iron • sugar • caffeine • obesity • population study

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