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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:968.)
© 2006 American Heart Association, Inc.

AHA Summary Statement

Obesity and Cardiovascular Disease

Pathophysiology, Evaluation, and Effect of Weight Loss

Paul Poirier; Thomas D. Giles; George A. Bray; Yuling Hong; Judith S. Stern; F. Xavier Pi-Sunyer; Robert H. Eckel

From the Quebec Heart and Lung Institute, Sainte-Foy.

Correspondence to Paul Poirier, Associate Professor of Pharmacy, Quebec Heart and Lung Institute, 2725, Chemin Sainte-Foy, Sainte-Foy, QC G1V 4G5, Canada. E-mail paul.poirier{at}crhl.ulaval.ca

Abstract

Obesity is becoming a global epidemic in both children and adults, and it is associated with numerous co-morbidities such as cardiovascular diseases (CVD), type 2 diabetes, hypertension, certain cancers, and sleep apnea/sleep-disordered breathing. In fact, is an independent risk factor for CVD and CVD risks have been also documented in obese children, and is associated with reduced life expectancy. A variety of adaptations/alterations in cardiac structure and function occur in the individual as adipose tissue accumulates in excess amount. As a whole, overweight/obesity predispose or is associated with numerous cardiac complications such as coronary heart disease, heart failure, and sudden death through its impact on the cardiovascular system.

Key Words: congestive heart failure • myocardial biology, structure

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