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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:435.)
© 2006 American Heart Association, Inc.

Brief Reviews

Applications of Nanotechnology to Atherosclerosis, Thrombosis, and Vascular Biology

Samuel A. Wickline; Anne M. Neubauer; Patrick Winter; Shelton Caruthers; Gregory Lanza

From Washington University, Departments of Medicine (S.A.W., P.W., G.L.) and Biomedical Engineering (S.A.W., A.M.N., G.L.), St Louis, Mo, and Philips Medical Systems (S.C.), Best, the Netherlands.

Correspondence to Samuel A. Wickline, Washington University School of Medicine, Campus Box 8086, 660 South Euclid Ave, St Louis, MO 63110. E-mail wicklines{at}aol.com

The role of nanotechnology in cardiovascular diagnosis is expanding rapidly. The goal of this brief review is to illustrate selected examples of nanosystems that have been applied to the arenas of atherosclerosis, thrombosis, and vascular biology. The technologies for producing targeted nanosystems are multifarious and reflect end uses in many cases. The results to date indicate rapid growth of interest and capability in the field. The future of cardiovascular diagnosis already is being impacted by nanosystems that can both diagnose pathology and treat it with targeted delivery systems.

Targeted nanotechnologies offer alternative modes of imaging for in vivo diagnosis and selective drug delivery that are expected to dramatically enhance molecular imaging capabilities and clinical prospects for personalized medicine in the near future.

Key Words: nanotechnology • contrast agents • imaging • drug therapy

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