This Article Full Text Full Text (PDF) All Versions of this Article: 26/3/435    most recent 01.ATV.0000201069.47550.8bv1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wickline, S. A. Articles by Lanza, G. Search for Related Content PubMed PubMed Citation Articles by Wickline, S. A. Articles by Lanza, G. Related Collections Cardiovascular imaging agents/Techniques Angiogenesis Pathophysiology Imaging Smooth muscle proliferation and differentiation Fibrinogen/fibrin Mechanism of atherosclerosis/growth factors

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:435.)
© 2006 American Heart Association, Inc.

Brief Reviews

Applications of Nanotechnology to Atherosclerosis, Thrombosis, and Vascular Biology

Samuel A. Wickline; Anne M. Neubauer; Patrick Winter; Shelton Caruthers; Gregory Lanza

From Washington University, Departments of Medicine (S.A.W., P.W., G.L.) and Biomedical Engineering (S.A.W., A.M.N., G.L.), St Louis, Mo, and Philips Medical Systems (S.C.), Best, the Netherlands.

Correspondence to Samuel A. Wickline, Washington University School of Medicine, Campus Box 8086, 660 South Euclid Ave, St Louis, MO 63110. E-mail wicklines{at}aol.com

The role of nanotechnology in cardiovascular diagnosis is expanding rapidly. The goal of this brief review is to illustrate selected examples of nanosystems that have been applied to the arenas of atherosclerosis, thrombosis, and vascular biology. The technologies for producing targeted nanosystems are multifarious and reflect end uses in many cases. The results to date indicate rapid growth of interest and capability in the field. The future of cardiovascular diagnosis already is being impacted by nanosystems that can both diagnose pathology and treat it with targeted delivery systems.

Targeted nanotechnologies offer alternative modes of imaging for in vivo diagnosis and selective drug delivery that are expected to dramatically enhance molecular imaging capabilities and clinical prospects for personalized medicine in the near future.

Key Words: nanotechnology • contrast agents • imaging • drug therapy

This article has been cited by other articles:

				R.-J. J.H.M. Miserus, M. V. Herias, L. Prinzen, M. B.I. Lobbes, R.-J. Van Suylen, A. Dirksen, T. M. Hackeng, J. W.M. Heemskerk, J. M.A. van Engelshoven, M. J.A.P. Daemen, et al. Molecular MRI of Early Thrombus Formation Using a Bimodal {alpha}2-Antiplasmin-Based Contrast Agent J. Am. Coll. Cardiol. Img., August 1, 2009; 2(8): 987 - 996. [Abstract] [Full Text] [PDF]

				R. P. Choudhury and E. A. Fisher Molecular Imaging in Atherosclerosis, Thrombosis, and Vascular Inflammation Arterioscler Thromb Vasc Biol, July 1, 2009; 29(7): 983 - 991. [Abstract] [Full Text] [PDF]

				K. Nakano, K. Egashira, S. Masuda, K. Funakoshi, G. Zhao, S. Kimura, T. Matoba, K. Sueishi, Y. Endo, Y. Kawashima, et al. Formulation of Nanoparticle-Eluting Stents by a Cationic Electrodeposition Coating Technology: Efficient Nano-Drug Delivery via Bioabsorbable Polymeric Nanoparticle-Eluting Stents in Porcine Coronary Arteries J. Am. Coll. Cardiol. Intv., April 1, 2009; 2(4): 277 - 283. [Abstract] [Full Text] [PDF]

				I. J. Sarembock From Systemic Shotgun to Site-Specific Nanoparticle-Targeted Delivery: A New Paradigm for Drug Delivery Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 1879 - 1881. [Full Text] [PDF]

				M. A. McAteer, J. E. Schneider, Z. A. Ali, N. Warrick, C. A. Bursill, C. von zur Muhlen, D. R. Greaves, S. Neubauer, K. M. Channon, and R. P. Choudhury Magnetic Resonance Imaging of Endothelial Adhesion Molecules in Mouse Atherosclerosis Using Dual-Targeted Microparticles of Iron Oxide Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 77 - 83. [Abstract] [Full Text] [PDF]

				F. A. Jaffer, P. Libby, and R. Weissleder Molecular Imaging of Cardiovascular Disease Circulation, August 28, 2007; 116(9): 1052 - 1061. [Full Text] [PDF]

				R. F. Mattrey Are Cerebral Emboli Real When Perfluorocarbon Emulsion (AF0144) is Used in Cardiac Surgery? Ann. Thorac. Surg., May 1, 2007; 83(5): 1922 - 1923. [Full Text] [PDF]

				X. Yang Nano- and Microparticle-based Imaging of Cardiovascular Interventions: Overview Radiology, May 1, 2007; 243(2): 340 - 347. [Abstract] [Full Text] [PDF]