Published online before print September 14, 2006, doi: 10.1161/01.ATV.0000245830.29764.84
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2006 American Heart Association, Inc.
Brief Reviews |
T Cells in Atherogenesis
For Better or For Worse?
From Section of Immunobiology and Howard Hughes Medical Institute (A.-K.L.R.), Yale University School of Medicine, New Haven, Conn; Center for Molecular Medicine (G.K.H.), Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Correspondence to Anna-Karin L Robertson, Yale School of Medicine, Immunobiology TAC S-560, PO Box 208011, New Haven, CT 06520. E-mail anna-karin.robertson{at}yale.edu
Series Editor: Göran K. Hansson Previous Brief Reviews in this Series:
•Nilsson J, Hansson GK, Shad PK. Immunomodulation of atherosclerosis: implications for vaccine development. 2005;25:18–28.
•Frostegård J. Atherosclerosis in patients with autoimmune disorders. 2005;25:1776–1785.
The idea that atherosclerosis is an inflammatory disease is no longer controversial. Instead, much of the current research is now focused on understanding what drives this inflammation and how it is regulated. Adaptive immunity, in particular T cells, is highly involved in atherogenesis. It is well known that different subsets of T cells can drive or dampen inflammatory processes, but we still have much to learn about the regulation of this balance in the context of atherosclerosis. This review summarizes our knowledge of T cells in atherogenesis, their potential antigens, their contact-dependent activities, and their secretion of inflammatory and antiinflammatory mediators, aiming to illustrate how T cells can aggravate or attenuate this disease through cross-talk with other cells within or outside the atherosclerotic plaque.
Adaptive immunity, in particular T cells, is highly involved in the development of atherosclerosis. This review summarizes our current knowledge of T cells in atherogenesis and illustrates how they can aggravate or attenuate this disease through cross-talk with other cells within or outside the atherosclerotic plaque.
Key Words: atherosclerosis pathophysiology • immune system • T cells • cytokines • macrophages
This article has been cited by other articles:
 |
|
 |
|
  N. Sasaki, T. Yamashita, M. Takeda, M. Shinohara, K. Nakajima, H. Tawa, T. Usui, and K.-i. Hirata Oral Anti-CD3 Antibody Treatment Induces Regulatory T Cells and Inhibits the Development of Atherosclerosis in Mice Circulation, November 17, 2009; 120(20): 1996 - 2005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Burioni, F. Canducci, D. Saita, M. Perotti, N. Mancini, D. De Marco, N. Clementi, A. Chieffo, M. Denaro, D. Cianflone, et al. Antigen-Driven Evolution of B Lymphocytes in Coronary Atherosclerotic Plaques J. Immunol., August 15, 2009; 183(4): 2537 - 2544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Khan, R. M. Gallo, G. J. Renukaradhya, W. Du, J. Gervay-Hague, and R. R. Brutkiewicz Statins Impair CD1d-Mediated Antigen Presentation through the Inhibition of Prenylation J. Immunol., April 15, 2009; 182(8): 4744 - 4750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Sandberg, B. Halvorsen, A. Yndestad, C. Smith, K. Otterdal, F. R. Brosstad, S. S. Froland, P. S. Olofsson, J. K. Damas, L. Gullestad, et al. Inflammatory Interaction Between LIGHT and Proteinase-Activated Receptor-2 in Endothelial Cells: Potential Role in Atherogenesis Circ. Res., January 2, 2009; 104(1): 60 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gomez, S. M. Sanz-Gonzalez, Y. N. A. Nabah, A. Lamana, F. Sanchez-Madrid, and V. Andres Atherosclerosis development in apolipoprotein E-null mice deficient for CD69 Cardiovasc Res, January 1, 2009; 81(1): 197 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ammirati, A.-C. Vermi, D. Cianflone, M. Banfi, C. Foglieni, C. Godino, F. Airoldi, L. A. Ferri, C. L. Gorman, A. A. Manfredi, et al. Expansion of T-Cell Receptor {zeta}dim Effector T Cells in Acute Coronary Syndromes Arterioscler Thromb Vasc Biol, December 1, 2008; 28(12): 2305 - 2311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R.S. Packard, E. Maganto-Garcia, I. Gotsman, I. Tabas, P. Libby, and A. H. Lichtman CD11c+ Dendritic Cells Maintain Antigen Processing, Presentation Capabilities, and CD4+ T-Cell Priming Efficacy Under Hypercholesterolemic Conditions Associated With Atherosclerosis Circ. Res., October 24, 2008; 103(9): 965 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kleemann, S. Zadelaar, and T. Kooistra Cytokines and atherosclerosis: a comprehensive review of studies in mice Cardiovasc Res, August 1, 2008; 79(3): 360 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Li Platelet-lymphocyte cross-talk J. Leukoc. Biol., May 1, 2008; 83(5): 1069 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Van Vre, H. Bult, V. Y. Hoymans, V. F.I. Van Tendeloo, C. J. Vrints, and J. M. Bosmans Human C-Reactive Protein Activates Monocyte-Derived Dendritic Cells and Induces Dendritic Cell-Mediated T-Cell Activation Arterioscler Thromb Vasc Biol, March 1, 2008; 28(3): 511 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Out, M. Hoekstra, K. Habets, I. Meurs, V. de Waard, R. B. Hildebrand, Y. Wang, G. Chimini, J. Kuiper, T. J.C. Van Berkel, et al. Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels Arterioscler Thromb Vasc Biol, February 1, 2008; 28(2): 258 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Srinivasan, D. T. Bolick, D. Lukashev, C. Lappas, M. Sitkovsky, K. R. Lynch, and C. C. Hedrick Sphingosine-1-Phosphate Reduces CD4+ T-Cell Activation in Type 1 Diabetes Through Regulation of Hypoxia-Inducible Factor Short Isoform I.1 and CD69 Diabetes, February 1, 2008; 57(2): 484 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. S. Packard and P. Libby Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction Clin. Chem., January 1, 2008; 54(1): 24 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Leeuwen, M. J.J. Gijbels, A. Duijvestijn, M. Smook, M. J. van de Gaar, P. Heeringa, M. P.J. de Winther, and J. W. C. Tervaert Accumulation of Myeloperoxidase-Positive Neutrophils in Atherosclerotic Lesions in LDLR / Mice Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 84 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Aukrust, A. Yndestad, W. J. Sandberg, L. Gullestad, and J. K. Damas T Cells in Coronary Artery Disease: Different Effects of Different T-Cell Subsets J. Am. Coll. Cardiol., October 9, 2007; 50(15): 1459 - 1461. [Full Text] [PDF]
|
|
|
|
|
|
K. Maiellaro and W. R. Taylor The role of the adventitia in vascular inflammation Cardiovasc Res, September 1, 2007; 75(4): 640 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Barlic and P. M. Murphy Chemokine regulation of atherosclerosis J. Leukoc. Biol., August 1, 2007; 82(2): 226 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Methe and M. Weis Atherogenesis and inflammation--was Virchow right? Nephrol. Dial. Transplant., July 1, 2007; 22(7): 1823 - 1827. [Full Text] [PDF]
|
|
|
|
|
|
D. J. Grainger TGF-{beta} and atherosclerosis in man Cardiovasc Res, May 1, 2007; 74(2): 213 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zal, C. Baboonian, and J. C. Kaski Letter to the Editor: Autoreactive CD4+CD28- T Cells and Acute Coronary Syndromes Arterioscler Thromb Vasc Biol, March 1, 2007; 27(3): E18 - E18. [Full Text] [PDF]
|
|