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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:2345.)
© 2006 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Serum Levels of Mannose-Binding Lectin and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women

Tymen T. Keller; Sander I. van Leuven; Marijn C. Meuwese; Nicholas J. Wareham; Robert Luben; Erik S. Stroes; C. Erik Hack; Marcel Levi; Kay-Tee Khaw; S. Matthijs Boekholdt

From the Departments of Vascular Medicine (T.T.K., S.I.v.L., M.C.M., E.S.S., M.L.) and Cardiology (S.M.B.), Academic Medical Center, Amsterdam, The Netherlands; Medical Research Council Epidemiology Unit (N.J.W.), Cambridge, United Kingdom; Department of Public Health and Primary Care (R.L., K.T.K.), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom; Department of Clinical Chemistry (E.H.), VU Medical Center, Amsterdam, The Netherlands.

Correspondence to T. T. Keller, Academic Medical Center of Amsterdam, Department of Vascular Medicine (Room F4-121), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. E-mail t.t.keller{at}amc.uva.nl

Objective— To determine the association between serum levels of mannose-binding lectin (MBL) and the risk of future coronary artery disease (CAD) in apparently healthy men and women.

Methods and Results— We performed a prospective case-control study among apparently healthy men and women nested in the EPIC-Norfolk cohort. Baseline concentrations of MBL were measured in serum samples of 946 patients who experienced a myocardial infarction or died of CAD during follow-up, and 1799 matched controls who remained free of CAD. Among men, median MBL levels were 1.63 ng/mL (interquartile range [IQR]: 0.59 to 3.80) in cases and 1.20 ng/mL (IQR: 0.48 to 3.37) in controls. Among women, median MBL levels were 1.02 ng/mL (IQR: 0.43 to 2.95) in cases and 1.01 ng/mL (IQR: 0.43 to 2.94) in controls. After adjustment, the odds ratio in men for future CAD was 1.59 (95% confidence interval [CI]: 1.09 to 2.32; P for linearity=0.01) for those in the highest quartile compared with those in the lowest quartile. In women no such relation was observed.

Conclusions— Elevated levels of MBL are associated with an increased risk of future CAD in apparently healthy men but not in women. The sex difference merits further exploration.

The purpose of this study was to determine the association between serum levels of mannose-binding lectin (MBL) and the risk of future coronary artery disease (CAD) in apparently healthy men and women. Elevated levels of MBL are associated with an increased risk of future CAD in apparently healthy men but not in women. The sex difference merits further exploration.

Key Words: atherosclerosis • coronary artery disease • inflammation • mannose-binding lectin

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