This Article Full Text Full Text (PDF) All Versions of this Article: 25/5/1038    most recent 01.ATV.0000161274.87407.26v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ishizaka, N. Articles by Yamakado, M. Search for Related Content PubMed PubMed Citation Articles by Ishizaka, N. Articles by Yamakado, M.

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:1038.)
© 2005 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Association Between Serum Uric Acid, Metabolic Syndrome, and Carotid Atherosclerosis in Japanese Individuals

Nobukazu Ishizaka; Yuko Ishizaka; Ei-Ichi Toda; Ryozo Nagai; Minoru Yamakado

From the Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine (N.I., R.N.), and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital (Y.I., E-I.T., M.Y.), Tokyo, Japan.

Correspondence to Dr Nobukazu Ishizaka, Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7-3-1 Bunkyo-ku, Tokyo 113-8655, Japan. E-mail nobuishizka-tky{at}umin.ac.jp

Objective— There are few data available on possible independent association between uric acid and carotid atherosclerosis. Here we first sought to investigate association between uric acid levels and metabolic syndrome in Japanese; second, we assessed whether there is an independent association of uric acid with prevalence of carotid atherosclerosis in individuals subdivided according to gender and metabolic syndrome status.

Methods and Results— Cross-sectional data from 8144 individuals who underwent general health screening were analyzed. After adjusting for age, total cholesterol, and smoking status, the odds ratios (95% CI) of sex-specific quartiles of serum uric acid for metabolic syndrome were 1.0, 1.06 (0.60 to 1.87), 2.18 (1.30 to 3.64), and 4.17 (2.56 to 6.79) in women, and 1.0, 0.92 (0.74 to 1.14), 1.52 (1.25 to 1.65), and 1.97 (1.61 to 2.40) in men. After adjusting for age, serum levels, total cholesterol, and smoking status, prevalence of carotid plaque was higher in subjects in the second, third, and fourth quartiles of uric acid level with odds ratios (95% CI) of 1.24 (1.01 to 1.52), 1.37 (1.11 to 1.68), and 1.31 (1.05 to 1.63), respectively, in men without metabolic syndrome but not in men with metabolic syndrome or in women with or without metabolic syndrome.

Conclusion— The prevalence of metabolic syndrome showed a graded increase according to serum uric acid values in both genders. In men who did not have metabolic syndrome, uric acid was found to be an independent risk factor for incidence of carotid plaque.

Whether there is an independent association of uric acid with prevalence of carotid atherosclerosis was analyzed. Serum uric acid values are associated with carotid plaque independently of other atherogenic risk factors in men without but not with metabolic syndrome or in women at all.

Key Words: metabolic syndrome • carotid atherosclerosis • ultrasonography • insulin resistance • multivariate analysis

This article has been cited by other articles:

				T. NEOGI, R. C. ELLISON, S. HUNT, R. TERKELTAUB, D. T. FELSON, and Y. ZHANG Serum Uric Acid Is Associated with Carotid Plaques: The National Heart, Lung, and Blood Institute Family Heart Study J Rheumatol, February 1, 2009; 36(2): 378 - 384. [Abstract] [Full Text] [PDF]

				L. Pacifico, V. Cantisani, C. Anania, E. Bonaiuto, F. Martino, R. Pascone, and C. Chiesa Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children Eur. J. Endocrinol., January 1, 2009; 160(1): 45 - 52. [Abstract] [Full Text] [PDF]

				L. G. Sanchez-Lozada, E. Tapia, P. Bautista-Garcia, V. Soto, C. Avila-Casado, I. P. Vega-Campos, T. Nakagawa, L. Zhao, M. Franco, and R. J. Johnson Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome Am J Physiol Renal Physiol, April 1, 2008; 294(4): F710 - F718. [Abstract] [Full Text] [PDF]

				K.-L. Chien, M.-F. Chen, H.-C. Hsu, W.-T. Chang, T.-C. Su, Y.-T. Lee, and F. B. Hu Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community Clin. Chem., February 1, 2008; 54(2): 310 - 316. [Abstract] [Full Text] [PDF]

				N. Ishizaka, Y. Ishizaka, E.-I. Toda, K. Koike, M. Yamakado, and R. Nagai Are Serum Carcinoembryonic Antigen Levels Associated With Carotid Atherosclerosis in Japanese Men? Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 160 - 165. [Abstract] [Full Text] [PDF]

				E. S. Ford, C. Li, S. Cook, and H. K. Choi Serum Concentrations of Uric Acid and the Metabolic Syndrome Among US Children and Adolescents Circulation, May 15, 2007; 115(19): 2526 - 2532. [Abstract] [Full Text] [PDF]

				C. Ruggiero, A. Cherubini, A. Ble, A. J.G. Bos, M. Maggio, V. D. Dixit, F. Lauretani, S. Bandinelli, U. Senin, and L. Ferrucci Uric acid and inflammatory markers Eur. Heart J., May 2, 2006; 27(10): 1174 - 1181. [Abstract] [Full Text] [PDF]

				C. Zoccali, R. Maio, F. Mallamaci, G. Sesti, and F. Perticone Uric Acid and Endothelial Dysfunction in Essential Hypertension J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1466 - 1471. [Abstract] [Full Text] [PDF]