This Article Full Text Full Text (PDF) All Versions of this Article: 24/9/1578    most recent 01.ATV.0000137390.56554.dfv1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tille, J.-C. Articles by Pepper, M.S. Search for Related Content PubMed PubMed Citation Articles by Tille, J.-C. Articles by Pepper, M.S. Related Collections Angiogenesis Animal models of human disease Genetically altered mice Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Genetics of Stroke

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1578.)
© 2004 American Heart Association, Inc.

Brief Reviews

Hereditary Vascular Anomalies

New Insights Into Their Pathogenesis

J.-C. Tille; M.S. Pepper

From the Departments of Clinical Pathology (J.-C.T.) and Morphology (M.S.P.), University Medical Center, Geneva, Switzerland.

Correspondence to Prof Michael S. Pepper, Department of Morphology, University Medical Center, 1, rue Michel Servet, 1211 Geneva 4, Switzerland. E-mail michael.pepper{at}medecine.unige.ch

Increased understanding of the mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular malformations. This review focuses on recent advances in our understanding of the mechanisms of angiogenesis/lymphangiogenesis and the differentiation of arterial, venous, and lymphatic vessels. We integrate this knowledge with new data obtained from genetic studies in humans, which have revealed a number of heretofore-unsuspected candidates involved in the development of familial vascular anomalies. We present a common infantile vascular tumor, hemangioma, and then focus on hereditary familial vascular and lymphatic malformations. We also summarize transgenic mouse models for some of these malformations. It seems reasonable to believe that novel therapeutic strategies will soon emerge for the treatment of hemangiomas and vascular malformations.

Increased understanding of the mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular malformations. This review focuses on recent advances in our understanding of the mechanisms of angiogenesis/lymphangiogenesis and the differentiation of arterial, venous, and lymphatic vessels. We integrate this knowledge with new data obtained from genetic studies in humans, which have revealed a number of heretofore-unsuspected candidates involved in the development of familial vascular anomalies. We present a common infantile vascular tumor, hemangioma, and then focus on hereditary familial vascular and lymphatic malformations. We also summarize transgenic mouse models for some of these malformations. It seems reasonable to believe that novel therapeutic strategies will soon emerge for the treatment of hemangiomas and vascular malformations.

Key Words: vascular malformation • angiogenesis • lymphangiogenesis

This article has been cited by other articles:

				R. I. Sadreyev, J. D. Feramisco, H. Tsao, and N. V. Grishin Phenotypic categorization of genetic skin diseases reveals new relations between phenotypes, genes and pathways Bioinformatics, November 15, 2009; 25(22): 2891 - 2896. [Abstract] [Full Text] [PDF]