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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1503.)
© 2004 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women

The EPIC-Norfolk Prospective Population Study

S. Matthijs Boekholdt; Ron J. G. Peters; C. Erik Hack; Nicholas E. Day; Robert Luben; Sheila A. Bingham; Nicholas J. Wareham; Pieter H. Reitsma; Kay-Tee Khaw

From the Department of Cardiology (S.M.B., R.J.G.P.) and the Laboratory for Experimental Internal Medicine (P.H.R.), Academic Medical Center, Amsterdam, the Netherlands; the Department of Public Health and Primary Care (N.E.D., R.L., N.J.W., K.T.K.), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom; the Medical Research Council Dunn Nutrition Unit (S.A.B.), Cambridge, United Kingdom; and the Sanquin Research at the Central Laboratory of the Blood Transfusion Service (C.E.H), Amsterdam, the Netherlands.

Correspondence to Kay-Tee Khaw, Clinical Gerontology Unit, Box 251 Addenbrooke’s Hospital, University of Cambridge School of Clinical Medicine, Cambridge CB2 2QQ, United Kingdom. E-mail kk101{at}medschl.cam.ac.uk

Objective— To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women.

Methods and Results— A nested case-control study was performed in the prospective EPIC-Norfolk population study. We measured baseline IL-8 concentrations among 785 apparently healthy individuals in whom fatal or nonfatal CAD developed during follow-up and 1570 matched controls. Baseline IL-8 concentrations were higher in cases than in matched controls (3.5 pg/mL versus 3.1 pg/mL, P=0.001). The risk of future CAD increased with increasing quartiles of IL-8 (P linearity <0.0001). Among individuals in the highest IL-8 quartile, the unadjusted odds ratio for future CAD was 1.72 (95% CI, 1.34 to 2.21; P<0.0001). The odds ratio for future CAD was still significant after adjustment for traditional risk factors (OR, 1.58; 95%CI, 1.19 to 2.09; P=0.002) and after additional adjustment for C-reactive protein and white cell count (OR, 1.77; 95% CI, 1.21 to 2.60; P=0.001).

Conclusions— We conclude that among apparently healthy men and women, elevated levels of IL-8 are associated with an increased risk of future CAD. These prospective data support a role for IL-8 in the development of CAD events.

Using a prospective nested case-control study among apparently healthy individuals, we found that high plasma levels of IL-8 were predictive for the risk of future coronary artery disease, independent of traditional risk factors and C-reactive protein levels.

Key Words: IL-8 • cytokines • coronary artery disease

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