Published online before print February 19, 2004, doi: 10.1161/01.ATV.0000122854.76267.5c
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2004 American Heart Association, Inc.
Brief Reviews |
Signaling in Leukocyte Transendothelial Migration
From Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.
Correspondence to Dr Peter L. Hordijk, Department of Experimental Immunohematology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands. E-mail p.hordijk{at}sanquin.nl
Under a variety of (patho) physiological conditions, leukocytes will leave the bloodstream by crossing the endothelial monolayer that lines the vessels and migrate into the underlying tissues. It is now clear that the process of extravasation involves a range of adhesion molecules on both leukocytes and endothelial cells, as well as extensive intracellular signaling that drives adhesion and chemotaxis on the one hand and controls a transient modulation of endothelial integrity on the other. We review here the current knowledge of the intracellular signaling pathways that are activated in the context of transendothelial migration in leukocytes and in endothelial cells. In leukocytes, polarization of receptors and of the signaling machinery is of key importance to drive adhesion and directional migration. Subsequent adhesion-induced signaling in endothelial cells, mediated by Rho-like GTPases and reactive oxygen species, induces a transient and focal loss of endothelial cell–cell adhesion to allow transmigration of the leukocyte. This review underscores the notion that we have likely just scratched the surface in revealing the complexity of the signaling that controls leukocyte transendothelial migration.
Key Words: endothelial cells • migration • Rho GTPases • adhesion • reactive oxygen species
This article has been cited by other articles:
 |
|
 |
|
  Y. Chiba, J. Arima, H. Sakai, and M. Misawa Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L705 - L713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. F. Bradfield, C. A. Johnson-Leger, C. Zimmerli, and B. A. Imhof LPS differentially regulates adhesion and transendothelial migration of human monocytes under static and flow conditions Int. Immunol., February 1, 2008; 20(2): 247 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dematteis, C. Julien, C. Guillermet, N. Sturm, S. Lantuejoul, M. Mallaret, P. Levy, and E. Gozal Intermittent Hypoxia Induces Early Functional Cardiovascular Remodeling in Mice Am. J. Respir. Crit. Care Med., January 15, 2008; 177(2): 227 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. van Buul, M. J. Allingham, T. Samson, J. Meller, E. Boulter, R. Garcia-Mata, and K. Burridge RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration J. Cell Biol., September 24, 2007; 178(7): 1279 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Su, H.-i. Chen, and C. J. Jen Polymorphonuclear leukocyte transverse migration induces rapid alterations in endothelial focal contacts J. Leukoc. Biol., September 1, 2007; 82(3): 542 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Sithu, W. R. English, P. Olson, D. Krubasik, A. H. Baker, G. Murphy, and S. E. D'Souza Membrane-type 1-Matrix Metalloproteinase Regulates Intracellular Adhesion Molecule-1 (ICAM-1)-mediated Monocyte Transmigration J. Biol. Chem., August 24, 2007; 282(34): 25010 - 25019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Malik, C. S. Bakshi, K. McCabe, S. V. Catlett, A. Shah, R. Singh, P. L. Jackson, A. Gaggar, D. W. Metzger, J. A. Melendez, et al. Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis J. Immunol., January 15, 2007; 178(2): 1013 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nourshargh, F. Krombach, and E. Dejana The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues J. Leukoc. Biol., October 1, 2006; 80(4): 714 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Liebner, U. Cavallaro, and E. Dejana The Multiple Languages of Endothelial Cell-to-Cell Communication Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1431 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Garton, P. J. Gough, and E. W. Raines Emerging roles for ectodomain shedding in the regulation of inflammatory responses J. Leukoc. Biol., June 1, 2006; 79(6): 1105 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Garrood, L. Lee, and C. Pitzalis Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways Rheumatology, March 1, 2006; 45(3): 250 - 260. [Full Text] [PDF]
|
|
|
|
|
|
J. Haorah, B. Knipe, J. Leibhart, A. Ghorpade, and Y. Persidsky Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction J. Leukoc. Biol., December 1, 2005; 78(6): 1223 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. de Rooij, A. Kerstens, G. Danuser, M. A. Schwartz, and C. M. Waterman-Storer Integrin-dependent actomyosin contraction regulates epithelial cell scattering J. Cell Biol., October 10, 2005; 171(1): 153 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. van Buul, E. C. Anthony, M. Fernandez-Borja, K. Burridge, and P. L. Hordijk Proline-rich Tyrosine Kinase 2 (Pyk2) Mediates Vascular Endothelial-Cadherin-based Cell-Cell Adhesion by Regulating {beta}-Catenin Tyrosine Phosphorylation J. Biol. Chem., June 3, 2005; 280(22): 21129 - 21136. [Abstract] [Full Text] [PDF]
|
|