This Article Full Text Full Text (PDF) All Versions of this Article: 24/10/1970    most recent 01.ATV.0000143134.87051.46v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Doggen, C. J.M. Articles by Psaty, B. M. Search for Related Content PubMed PubMed Citation Articles by Doggen, C. J.M. Articles by Psaty, B. M. Related Collections Deep vein thrombosis Thrombosis risk factors Lipid and lipoprotein metabolism

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1970.)
© 2004 American Heart Association, Inc.

Thrombosis

Serum Lipid Levels and the Risk of Venous Thrombosis

Carine J.M. Doggen; Nicholas L. Smith; Rozenn N. Lemaitre; Susan R. Heckbert; Frits R. Rosendaal; Bruce M. Psaty

From the Departments of Epidemiology (C.J.M.D., N.L.S., S.R.H., F.R.R., B.M.P.), Medicine (R.N.L., B.M.P.), and Health Services (B.M.P.), University of Washington, Seattle; and the Departments of Clinical Epidemiology (C.J.M.D., F.R.R.) and Hematology (F.R.R.), Leiden University Medical Center, Leiden, the Netherlands.

Correspondence to Carine J.M. Doggen, Clinical Epidemiology, Albinusdreef 2, Leiden University Medical Center C9-P, PO Box 9600, 2300 RC Leiden, the Netherlands. E-mail C.J.M.Doggen{at}lumc.nl

Objective— Lipids, through effects on the coagulation and fibrinolytic systems, may contribute to the development of venous thrombosis. This association has been investigated in a few studies, with conflicting results.

Methods and Results— We conducted a population-based, case-control study at a health maintenance organization in Washington State, to assess the association of serum lipid levels with the risk of venous thrombosis. Cases were 477 postmenopausal women with a first venous thrombosis during January 1995 through December 2001. Control subjects (1986) were a random sample of postmenopausal women. Medical records, computerized pharmacy databases, and a cancer registry served to collect data on lipid levels and risk factors for thrombosis. Total cholesterol levels were not associated with venous thrombosis. Only high HDL cholesterol levels were associated with a decreased risk of venous thrombosis after adjustment for hospitalization, malignancy, height and weight, postmenopausal hormone therapy, and vascular disease (for high-density lipoprotein [HDL] cholesterol levels >1.79 mmol/L versus those <1.79 mmol/L; odds ratio [OR], 0.71; 95% confidence interval [CI], 0.52 to 0.97). In contrast, elevated triglyceride levels were associated with an increased risk (OR, 2.13; 95% CI, 1.34 to 3.37) for women with triglyceride levels >1.05 mmol/L compared with women with lower levels.

Conclusion— Elevated triglyceride levels were associated with a doubling of risk of venous thrombosis in postmenopausal women, whereas elevated HDL cholesterol levels were associated with a decreased risk.

In a population-based case-control study including 477 postmenopausal women with a first venous thrombosis and 1986 control subjects, elevated triglyceride levels were associated with a 2-fold increased risk of venous thrombosis, whereas high HDL cholesterol was associated with a decreased risk. Total cholesterol levels were not associated with venous thrombosis.

Key Words: total cholesterol • high-density lipoprotein cholesterol • triglycerides • venous thrombosis • risk

This article has been cited by other articles:

				A. C. Calkin, B. G. Drew, A. Ono, S. J. Duffy, M. V. Gordon, S. M. Schoenwaelder, D. Sviridov, M. E. Cooper, B. A. Kingwell, and S. P. Jackson Reconstituted High-Density Lipoprotein Attenuates Platelet Function in Individuals With Type 2 Diabetes Mellitus by Promoting Cholesterol Efflux Circulation, November 24, 2009; 120(21): 2095 - 2104. [Abstract] [Full Text] [PDF]

				A. M. Chamberlain, A. R. Folsom, S. R. Heckbert, W. D. Rosamond, and M. Cushman High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE) Blood, October 1, 2008; 112(7): 2675 - 2680. [Abstract] [Full Text] [PDF]

				W. Ageno, C. Becattini, T. Brighton, R. Selby, and P. W. Kamphuisen Cardiovascular Risk Factors and Venous Thromboembolism: A Meta-Analysis Circulation, January 1, 2008; 117(1): 93 - 102. [Abstract] [Full Text] [PDF]

				G. Orti, Y. Mira, and A. Vaya Acute Myocardial Infarction Associated With Yasmin Oral Contraceptive Clinical and Applied Thrombosis/Hemostasis, July 1, 2007; 13(3): 336 - 337. [PDF]

				R. S. Birjmohun, S. I. van Leuven, J. H.M. Levels, C. van 't Veer, J. A. Kuivenhoven, J. C.M. Meijers, M. Levi, J. J.P. Kastelein, T. van der Poll, and E. S.G. Stroes High-Density Lipoprotein Attenuates Inflammation and Coagulation Response on Endotoxin Challenge in Humans Arterioscler Thromb Vasc Biol, May 1, 2007; 27(5): 1153 - 1158. [Abstract] [Full Text] [PDF]

				S. Eichinger, N. M. Pecheniuk, G. Hron, H. Deguchi, M. Schemper, P. A. Kyrle, and J. H. Griffin High-Density Lipoprotein and the Risk of Recurrent Venous Thromboembolism Circulation, March 27, 2007; 115(12): 1609 - 1614. [Abstract] [Full Text] [PDF]

				F. Dentali, E. Romualdi, and W. Ageno The metabolic syndrome and the risk of thrombosis Haematologica, March 1, 2007; 92(3): 297 - 299. [Full Text] [PDF]

				C. Ay, T. Tengler, R. Vormittag, R. Simanek, W. Dorda, T. Vukovich, and I. Pabinger Venous thromboembolism a manifestation of the metabolic syndrome Haematologica, March 1, 2007; 92(3): 374 - 380. [Abstract] [Full Text] [PDF]

				A. Kontush and M. J. Chapman Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis Pharmacol. Rev., September 1, 2006; 58(3): 342 - 374. [Abstract] [Full Text] [PDF]

				J M Ricart, A Vaya, M Santaolaria, F Espana, and J Aznar Dyslipidaemia in Behcet's disease as a thrombotic risk factor Ann Rheum Dis, September 1, 2006; 65(9): 1248 - 1249. [Full Text] [PDF]

				C. Mineo, H. Deguchi, J. H. Griffin, and P. W. Shaul Endothelial and Antithrombotic Actions of HDL Circ. Res., June 9, 2006; 98(11): 1352 - 1364. [Abstract] [Full Text] [PDF]

				R. Liperoti, C. Pedone, K. L. Lapane, V. Mor, R. Bernabei, and G. Gambassi Venous Thromboembolism Among Elderly Patients Treated With Atypical and Conventional Antipsychotic Agents Arch Intern Med, December 12, 2005; 165(22): 2677 - 2682. [Abstract] [Full Text] [PDF]

				W. Sturm, A. Sandhofer, C. J.M. Doggen, N. L. Smith, R. N. Lemaitre, S. R. Heckbert, F. R. Rosendaal, and B. M. Psaty Dyslipidemia and Thrombosis: Causal Relationship or Epiphenomenon of Sedentary Lifestyle? Arterioscler Thromb Vasc Biol, March 1, 2005; 25(3): e19 - e19. [Full Text] [PDF]