This Article Full Text Full Text (PDF) All Versions of this Article: 24/10/1874    most recent 01.ATV.0000140060.13203.22v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Obisesan, T. O. Articles by Hagberg, J. M. Search for Related Content PubMed PubMed Citation Articles by Obisesan, T. O. Articles by Hagberg, J. M.

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:1874.)
© 2004 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

C-Reactive Protein Genotypes Affect Baseline, but not Exercise Training–Induced Changes, in C-Reactive Protein Levels

Thomas O. Obisesan; Christiaan Leeuwenburgh; Tracey Phillips; Robert E. Ferrell; Dana A. Phares; Steven J. Prior; James M. Hagberg

From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

Correspondence to Dr James Hagberg, Department of Kinesiology, University of Maryland, College Park, MD 20742-2611. E-mail hagberg{at}umd.edu

Objective— The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels.

Methods and Results— Sixty-three sedentary men and women aged 50 to 75 years old underwent baseline testing (VOmax, body composition, CRP levels). They repeated these tests after 24 weeks of exercise training while on a low-fat diet. The CRP +219G/A variant significantly associated with CRP levels before and after training after accounting for the effects of demographic and biological variables. CRP –732A/G genotype was significantly related on a univariate basis to CRP levels after training. The CRP +29T/A variant did not affect CRP levels before or after training. In regression analyses, the +219 and –732 variants each had significant effects on CRP levels before and after training. Subjects homozygous for the common A/G –732/+219 haplotype exhibited the highest CRP levels, and having the rare allele at either site was associated with significantly lower CRP levels. CRP levels decreased significantly with training (–0.38±0.18 mg/L; P=0.03). However, none of the CRP variants was associated with the training-induced CRP changes.

Conclusion— CRP +219G/A and –732A/G genotypes and haplotypes and exercise training appear to modulate CRP levels. However, training-induced CRP reductions appear to be independent of genotype at these loci.

We determined whether CRP gene variants affect baseline CRP levels and whether these variants interact with exercise training to affect CRP levels. CRP +219G/A and –732A/G genotypes and exercise training appear to modulate CRP levels. However, the training-induced CRP reductions appear to be independent of genotype at these loci.

Key Words: C-reactive protein • genetics • exercise training

This article has been cited by other articles:

				T. B. Grammer, W. Marz, W. Renner, B. O. Bohm, and M. M. Hoffmann C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease: the LURIC study Eur. Heart J., January 2, 2009; 30(2): 170 - 182. [Abstract] [Full Text] [PDF]

				L. Gallicchio, H. Chang, D. K. Christo, L. Thuita, H.-Y. Huang, P. Strickland, I. Ruczinski, S. C. Hoffman, and K. J. Helzlsouer Single Nucleotide Polymorphisms in Inflammation-related Genes and Mortality in a Community-based Cohort in Washington County, Maryland Am. J. Epidemiol., April 1, 2008; 167(7): 807 - 813. [Abstract] [Full Text] [PDF]

				F. G. Hage and A. J. Szalai C-Reactive Protein Gene Polymorphisms, C-Reactive Protein Blood Levels, and Cardiovascular Disease Risk J. Am. Coll. Cardiol., September 18, 2007; 50(12): 1115 - 1122. [Abstract] [Full Text] [PDF]

				C. M. Paton, J. Brandauer, E. P. Weiss, M. D. Brown, F. M. Ivey, S. M. Roth, and J. M. Hagberg Hemostatic response to postprandial lipemia before and after exercise training J Appl Physiol, July 1, 2006; 101(1): 316 - 321. [Abstract] [Full Text] [PDF]

				I. Kardys, M. P.M. de Maat, A. G. Uitterlinden, A. Hofman, and J. C.M. Witteman C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study Eur. Heart J., June 1, 2006; 27(11): 1331 - 1337. [Abstract] [Full Text] [PDF]

				K. K. Koh, S. H. Han, and M. J. Quon Inflammatory Markers and the Metabolic Syndrome: Insights From Therapeutic Interventions J. Am. Coll. Cardiol., December 6, 2005; 46(11): 1978 - 1985. [Abstract] [Full Text] [PDF]

				A. W. Zieske, R. P. Tracy, C. A. McMahan, E. E. Herderick, S. Homma, G. T. Malcom, H. C. McGill Jr, J. P. Strong, and for the Pathobiological Determinants of Atheroscle Elevated Serum C-Reactive Protein Levels and Advanced Atherosclerosis in Youth Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1237 - 1243. [Abstract] [Full Text] [PDF]

				K. Esposito, R. Marfella, D. Giugliano, T. O. Obisesan, J. M. Hagberg, K. Okita, H. Nishijima, and T. Murakami Fitness Versus Fatness: the Debate Continues Arterioscler Thromb Vasc Biol, March 1, 2005; 25(3): e20 - e21. [Full Text] [PDF]

				J.-P. Despres CRP and Risk of Coronary Heart Disease: Can Exercise Training Cool Down the Flames? Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1743 - 1745. [Full Text] [PDF]